{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:15:53Z","timestamp":1759335353282},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1410,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Cell. Biochem."],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1002\/jcb.23286","type":"journal-article","created":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T14:02:29Z","timestamp":1311688949000},"page":"3630-3637","source":"Crossref","is-referenced-by-count":29,"title":["High CJD infectivity remains after prion protein is destroyed"],"prefix":"10.1002","volume":"112","author":[{"given":"Kohtaro","family":"Miyazawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaitlin","family":"Emmerling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Manuelidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,22]]},"reference":[{"key":"10.1002\/jcb.23286-BIB1|cit1","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/nar\/22.6.1101","article-title":"Endogenous viral complexes with long RNA cosediment with the agent of Creutzfeldt-Jakob disease","volume":"22","author":"Akowitz","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"10.1002\/jcb.23286-BIB2|cit2","doi-asserted-by":"crossref","first-page":"8768","DOI":"10.1073\/pnas.0400158101","article-title":"Two Creutzfeldt-Jakob disease agents reproduce prion protein-independent identities in cell cultures","volume":"101","author":"Arjona","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/jcb.23286-BIB3|cit3","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nmeth1066","article-title":"Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein","volume":"4","author":"Atarashi","year":"2007","journal-title":"Nat Methods"},{"key":"10.1002\/jcb.23286-BIB4|cit4","doi-asserted-by":"crossref","first-page":"10905","DOI":"10.1128\/JVI.76.21.10905-10913.2002","article-title":"Microglia from CJD brain are infectious and show specific mRNA activation profiles","volume":"76","author":"Baker","year":"2002","journal-title":"J Virol"},{"key":"10.1002\/jcb.23286-BIB5|cit5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0272-2712(02)00067-7","article-title":"A gene-targeted mouse model of P102L Gerstmann-Straussler-Scheinker syndrome","volume":"1","author":"Barron","year":"2003","journal-title":"Clin Lab Med"},{"key":"10.1002\/jcb.23286-BIB6|cit6","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1146\/annurev.biochem.78.082907.145410","article-title":"Getting a grip on prions: Oligomers, amyloids, and pathological membrane interactions","volume":"78","author":"Caughey","year":"2009","journal-title":"Annu Rev Biochem"},{"key":"10.1002\/jcb.23286-BIB7|cit7","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006833","article-title":"Prions","volume":"3","author":"Colby","year":"2011","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1002\/jcb.23286-BIB8|cit8","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/BJ20081235","article-title":"Detection and characterization of proteinase K-sensitive disease-related prion protein with thermolysin","volume":"416","author":"Cronier","year":"2008","journal-title":"Biochem J"},{"key":"10.1002\/jcb.23286-BIB9|cit9","doi-asserted-by":"crossref","first-page":"e15679","DOI":"10.1371\/journal.pone.0015679","article-title":"Isolation of proteinase K-sensitive prions using pronase E and phosphotungstic acid","volume":"5","author":"D'Castro","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1002\/jcb.23286-BIB10|cit10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/30090","article-title":"The fraud of Abderhalden's enzymes","volume":"393","author":"Deichmann","year":"1998","journal-title":"Nature"},{"key":"10.1002\/jcb.23286-BIB11|cit11","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/306476a0","article-title":"Scrapie infectivity, fibrils and low molecular weight protein","volume":"306","author":"Diringer","year":"1983","journal-title":"Nature"},{"key":"10.1002\/jcb.23286-BIB12|cit12","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/path.1962","article-title":"Transportation of prion protein across the intestinal mucosa of scrapie-susceptible and scrapie-resistant sheep","volume":"209","author":"Jeffrey","year":"2006","journal-title":"J Pathol"},{"key":"10.1002\/jcb.23286-BIB13|cit13","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1099\/0022-1317-70-8-2017","article-title":"The genomic identity of different strains of mouse scrapie is expressed in hamsters and preserved on reisolation in mice","volume":"70","author":"Kimberlin","year":"1989","journal-title":"J Gen Virol"},{"key":"10.1002\/jcb.23286-BIB14|cit14","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/446136a","article-title":"Abderhalden's fraud still wins him some supporters","volume":"446","author":"Kutschera","year":"2007","journal-title":"Nature"},{"key":"10.1002\/jcb.23286-BIB15|cit15","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1080\/13550280802105283","article-title":"A rapid accurate culture assay for infectivity in transmissible encephalopathies","volume":"14","author":"Liu","year":"2008","journal-title":"J Neurovirol"},{"key":"10.1002\/jcb.23286-BIB16|cit16","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/jcb.20220","article-title":"New molecular markers of early and progressive CJD brain infection","volume":"93","author":"Lu","year":"2004","journal-title":"J Cell Biochem"},{"key":"10.1002\/jcb.23286-BIB17|cit17","doi-asserted-by":"crossref","first-page":"20908","DOI":"10.1073\/pnas.0710054104","article-title":"Prion strain discrimination in cell culture: The cell panel assay","volume":"104","author":"Mahal","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/jcb.23286-BIB18|cit18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3109\/13550289709015793","article-title":"Decontamination of Creutzfeldt-Jakob disease and other transmissible agents","volume":"3","author":"Manuelidis","year":"1997","journal-title":"J Neurovirol"},{"key":"10.1002\/jcb.23286-BIB19|cit19","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1073\/pnas.95.5.2520","article-title":"Vaccination with an attenuated CJD strain prevents expression of a virulent agent","volume":"95","author":"Manuelidis","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/jcb.23286-BIB20|cit20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1089\/088282403322017875","article-title":"Transmissible encephalopathies: Speculations and realities","volume":"16","author":"Manuelidis","year":"2003","journal-title":"Viral Immunol"},{"key":"10.1002\/jcb.23286-BIB21|cit21","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/jcb.21090","article-title":"A 25\u2009nm virion is the likely cause of transmissible spongiform encephalopathies","volume":"100","author":"Manuelidis","year":"2007","journal-title":"J Cell Biochem"},{"key":"10.1002\/jcb.23286-BIB22|cit22","first-page":"131","article-title":"Nuclease resistant circular DNAs copurify with infectivity in scrapie and CJD","volume":"2","author":"Manuelidis","year":"2010","journal-title":"J Neurovirol"},{"key":"10.1002\/jcb.23286-BIB23|cit23","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1006\/viro.1996.0033","article-title":"Infectivity and host responses in Creutzfeldt-Jakob disease","volume":"216","author":"Manuelidis","year":"1996","journal-title":"Virology"},{"key":"10.1002\/jcb.23286-BIB24|cit24","first-page":"489","volume-title":"Unconventional virus diseases of the central nervous system, Masson","author":"Manuelidis","year":"1989"},{"key":"10.1002\/jcb.23286-BIB25|cit25","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.1073\/pnas.92.11.5124","article-title":"Viral particles are required for infection in neurodegenerative Creutzfeldt-Jakob disease","volume":"92","author":"Manuelidis","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/jcb.23286-BIB26|cit26","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1126\/science.277.5322.94","article-title":"Evolution of a strain of CJD that induces BSE-like plaques","volume":"277","author":"Manuelidis","year":"1997","journal-title":"Science"},{"key":"10.1002\/jcb.23286-BIB27|cit27","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1073\/pnas.0610999104","article-title":"Cells infected with scrapie and Creutzfeldt-Jakob disease agents produce intracellular 25-nm virus-like particles","volume":"104","author":"Manuelidis","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/jcb.23286-BIB28|cit28","doi-asserted-by":"crossref","first-page":"13529","DOI":"10.1073\/pnas.0905825106","article-title":"The kuru infectious agent is a unique geographic isolate distinct from Creutzfeldt-Jakob disease and scrapie agents","volume":"106","author":"Manuelidis","year":"2009a","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/jcb.23286-BIB29|cit29","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/jcb.21988","article-title":"Strain-specific viral properties of variant Creutzfeldt-Jakob disease (vCJD) are encoded by the agent and not by host prion protein","volume":"106","author":"Manuelidis","year":"2009b","journal-title":"J Cell Biochem"},{"key":"10.1002\/jcb.23286-BIB30|cit30","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0092-8674(83)90207-6","article-title":"A protease-resistant protein is a structural component of the scrapie prion","volume":"35","author":"McKinley","year":"1983","journal-title":"Cell"},{"key":"10.1002\/jcb.23286-BIB31|cit31","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/306474a0","article-title":"Scrapie associated fibrils in Creutzfeldt-Jakob disease","volume":"306","author":"Merz","year":"1983","journal-title":"Nature"},{"key":"10.1002\/jcb.23286-BIB32|cit32","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1271\/bbb.70.1246","article-title":"Degradation of PrP(Sc) by keratinolytic protease from Nocardiopsis sp. TOA-1","volume":"70","author":"Mitsuiki","year":"2006","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1002\/jcb.23286-BIB33|cit33","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/jcb.22723","article-title":"Proliferative arrest of neural cells induces prion protein synthesis, nanotube formation, and cell-to-cell contacts","volume":"111","author":"Miyazawa","year":"2010","journal-title":"J Cell Biochem"},{"key":"10.1002\/jcb.23286-BIB34|cit34","doi-asserted-by":"crossref","first-page":"188","DOI":"10.4161\/viru.2.3.15880","article-title":"Replication and spread of CJD, kuru and scrapie in vivo and in cell culture","volume":"2","author":"Miyazawa","year":"2011","journal-title":"Virulence"},{"key":"10.1002\/jcb.23286-BIB35|cit35","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1126\/science.1118155","article-title":"Reciprocal interference between specific CJD and scrapie agents in neural cell cultures","volume":"310","author":"Nishida","year":"2005","journal-title":"Science"},{"key":"10.1002\/jcb.23286-BIB36|cit36","doi-asserted-by":"crossref","first-page":"13363","DOI":"10.1073\/pnas.95.23.13363","article-title":"Prions","volume":"95","author":"Prusiner","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/jcb.23286-BIB37|cit37","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1863-2378.2007.01040.x","article-title":"Infectivity of scrapie prion protein (PrPSc) following in vitro digestion with bovine gastrointestinal microbiota","volume":"54","author":"Scherbel","year":"2007","journal-title":"Zoonoses Public Health"},{"key":"10.1002\/jcb.23286-BIB38|cit38","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0140-6736(02)09513-2","article-title":"Postexposure prophylaxis against prion disease with a stimulator of innate immunity","volume":"360","author":"Sethi","year":"2002","journal-title":"Lancet"},{"key":"10.1002\/jcb.23286-BIB39|cit39","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1128\/JVI.63.3.1212-1222.1989","article-title":"Physical properties of the Creutzfeldt-Jakob disease agent","volume":"63","author":"Sklaviadis","year":"1989","journal-title":"J Virol"},{"issue":"7","key":"10.1002\/jcb.23286-BIB40|cit40","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1099\/vir.0.030452-0","article-title":"Characterization of the effect of heat on agent strains of the transmissible spongiform encephalopathies","volume":"92","author":"Somerville","year":"2011","journal-title":"J Gen Virol"},{"key":"10.1002\/jcb.23286-BIB41|cit41","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1089\/vim.2008.0039","article-title":"Quantitative recovery of scrapie agent with minimal protein from highly infectious cultures","volume":"21","author":"Sun","year":"2008","journal-title":"Viral Immunol"},{"key":"10.1002\/jcb.23286-BIB42|cit42","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1292\/jvms.70.159","article-title":"Conformational change in hamster scrapie prion protein (PrP27-30) associated with proteinase K resistance and prion infectivity","volume":"70","author":"Suzuki","year":"2008","journal-title":"J Vet Med Sci"},{"key":"10.1002\/jcb.23286-BIB43|cit43","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0092-8674(95)90236-8","article-title":"Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein","volume":"83","author":"Telling","year":"1995","journal-title":"Cell"},{"key":"10.1002\/jcb.23286-BIB44|cit44","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1126\/science.1183748","article-title":"Generating a prion with bacterially expressed recombinant prion protein","volume":"327","author":"Wang","year":"2010","journal-title":"Science"},{"key":"10.1002\/jcb.23286-BIB45|cit45","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1111\/j.1365-2672.2006.03080.x","article-title":"Characterization of a proteolytic enzyme derived from a Bacillus strain that effectively degrades prion protein","volume":"102","author":"Yoshioka","year":"2007","journal-title":"J Appl Microbiol"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.23286","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/jcb.23286\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T09:35:46Z","timestamp":1613554546000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/jcb.23286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,22]]},"references-count":45,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"URL":"https:\/\/doi.org\/10.1002\/jcb.23286","relation":{},"ISSN":["0730-2312"],"issn-type":[{"value":"0730-2312","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10,22]]}}}