{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:45:54Z","timestamp":1758278754591},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,2,19]],"date-time":"2004-02-19T00:00:00Z","timestamp":1077148800000},"content-version":"vor","delay-in-days":7354,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Both the insulin receptor and the gene product of the Rous sarcoma virus, pp60<jats:sup>src<\/jats:sup>, are protein kinases which phosphorylate themselves and other proteins on tyrosinc residues. Addition of the solubilized insulin receptor to purified pp60<jats:sup>src<\/jats:sup> increased the phosphorylation of the \u03b2\u2010subunit of the insulin receptor. Phosphorylation of the insulin receptor by pp60<jats:sup>src<\/jats:sup> occurred both in the absence and presence of insulin but did not alter the insulin dose response for autophosphorylation of the receptor. Increasing concentrations of pp60<jats:sup>src<\/jats:sup> increased the phosphorylation of the receptor and at high concentrations equaled the maximal effect produced by insulin. Our observations suggest a possible mechanism by which the metabolically regulated insulin receptor tyrosine kinase could be altered by other tyrosine kinases such as that associated with pp60<jats:sup>src<\/jats:sup>. Further studies will be required to determine if the insulin receptor is phosphorylated by pp60<jats:sup>src<\/jats:sup> in Rous sarcoma virus\u2010infected cells.<\/jats:p>","DOI":"10.1002\/jcb.240260305","type":"journal-article","created":{"date-parts":[[2004,12,30]],"date-time":"2004-12-30T07:28:41Z","timestamp":1104391721000},"page":"169-179","source":"Crossref","is-referenced-by-count":6,"title":["Phosphorylation of the solubilized insulin receptor by the gene product of the Rous sarcoma virus, pp60<sup>src<\/sup>"],"prefix":"10.1002","volume":"26","author":[{"given":"Morris F.","family":"White","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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