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Our results indicate that the surface insulin receptors turn over faster in diabetic cells than in nondiabetic cells. In addition, fewer receptors are incorporated into the plasma membrane per hour in diabetic cells than in nondiabetic cells. It is possible to propose a model to account for the altered expression of surface insulin receptors in diabetic cells on the basis of abnormalities of receptor incorporation and turnover.<\/jats:p>","DOI":"10.1002\/jcb.240280109","type":"journal-article","created":{"date-parts":[[2004,12,30]],"date-time":"2004-12-30T08:49:24Z","timestamp":1104396564000},"page":"59-67","source":"Crossref","is-referenced-by-count":1,"title":["Increased turnover of surface insulin receptors in fibroblastic cultures from genetically diabetic (DB\/DB) mice"],"prefix":"10.1002","volume":"28","author":[{"given":"Ranjana","family":"Kadle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohan K.","family":"Raizada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Fellows","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,19]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"23","volume":"24","author":"Bar RS","year":"1979","journal-title":"Adv Int Med"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-43-1-226"},{"key":"e_1_2_1_4_2","first-page":"E15","volume":"243","author":"Olefsky JM","year":"1982","journal-title":"Am J Physiol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.32.6.541"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-55-1-123"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-54-2-261"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.30.7.596"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"9149","DOI":"10.1016\/S0021-9258(19)70539-0","volume":"255","author":"Raizada MK","year":"1980","journal-title":"J Biol Chem"},{"key":"e_1_2_1_10_2","first-page":"4043","volume":"42","author":"Kadle R","year":"1983","journal-title":"Fed. 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