{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T11:42:17Z","timestamp":1697888537728},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,2,19]],"date-time":"2004-02-19T00:00:00Z","timestamp":1077148800000},"content-version":"vor","delay-in-days":6988,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ornithine decarboxylase, the rate\u2010limiting enzyme in polyamine biosynthesis, has been shown to be regulated in thyroid by thyrotropin both in vivo and in vitro. Little, however, is known of the role of polyamines in thyroid cell function. Since studies in other tissues suggest that polyamines may influence protein phosphorylation, we studied the effect of the polyamines on various protein kinase activities in rat thyroid. Putrescine, spermidine, and spermine inhibit cyclic\u2010AMP\u2010dependent histone H<jats:sub>1<\/jats:sub> kinase activity when measured in the cytosol fraction of rat thyroid; this effect is largely reproduced by NaCl concentrations of equivalent ionic strength. Both spermidine and spermine effect a 1.6\u20132.4\u2010fold increase in cytosolic cyclic\u2010AMP\u2010independent (messenger\u2010independent) casein kinase activity; stimulation by both polyamines is maximal at 5mM. A similar profile of stimulation is observed for messenger\u2010independent casein kinase activity in crude nuclear preparations. Sodium chloride fails to stimulate both cytosolic and nuclear messenger\u2010independent casein kinase activities at ionic strength equivalent to the spermine concentrations used. Spermine, but not putrescine, spermidine, or sodium chloride, inhibits calcium\/phospholipid\u2010dependent protein kinase C activity in cytosol extracts partially purified by DEAE chromatography. These findings suggest that regulation of protein kinase(s) by polyamines may represent a proximal locus (i) of action of thyrotropin\u2010regulated ornithine decarboxylase activity in thyroid.<\/jats:p>","DOI":"10.1002\/jcb.240280408","type":"journal-article","created":{"date-parts":[[2004,12,30]],"date-time":"2004-12-30T13:29:31Z","timestamp":1104413371000},"page":"299-306","source":"Crossref","is-referenced-by-count":7,"title":["Differential effects of polyamines on rat thyroid protein kinase activities"],"prefix":"10.1002","volume":"28","author":[{"given":"Steven","family":"Levasseur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorraine","family":"Henricks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Poleck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yochanan","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Burke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-97-5-1089"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-96-6-1403"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj1954.22.339"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(77)80164-2"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-104-2-467"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj1954.25.129"},{"key":"e_1_2_1_8_2","first-page":"1","volume-title":"Advances in Polyamine Research","author":"Cohen SS","year":"1978"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-419X(78)90015-X"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(83)90062-X"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/S0021-9258(17)33765-1","volume":"215","author":"Takai Y","year":"1976","journal-title":"J Biol Chem"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(76)90777-4"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(78)90252-7"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(78)90002-4"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(77)90267-7"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1760739"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)50558-5"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.48.070179.004423"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(84)90061-3"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1042\/bj1720433","volume":"172","author":"Menon KMJ","year":"1978","journal-title":"Biochem J"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0620315"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-91-5-1259"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(76)80653-9"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2744(77)90089-4"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(79)90102-3"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(79)80271-9"},{"key":"e_1_2_1_28_2","first-page":"23","volume":"3","author":"Combest WL","year":"1979","journal-title":"J Supramol Struct"},{"key":"e_1_2_1_29_2","first-page":"T\u201027","volume":"5","author":"Friedman Y","year":"1984","journal-title":"Endocrinology"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj1954.21.529"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(75)90588-4"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.6.2541"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.4.1174"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(74)80244-5"},{"key":"e_1_2_1_35_2","doi-asserted-by":"crossref","first-page":"5408","DOI":"10.1016\/S0021-9258(17)33176-9","volume":"251","author":"Hirsch J","year":"1976","journal-title":"J Biol Chem"},{"key":"e_1_2_1_36_2","doi-asserted-by":"crossref","first-page":"6750","DOI":"10.1016\/S0021-9258(17)39913-1","volume":"252","author":"Kranias EG","year":"1977","journal-title":"J Biol Chem"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-103-6-2334"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-115-6-2324"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1977.tb11347.x"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)34358-8"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2130281"},{"key":"e_1_2_1_42_2","unstructured":"FriedmanY PoleckT HenricksL BurkeG: 7th International Congress of Endocrinology\u2014Satellite Symposium. Montreal Canada (Abstract) June 28\u201330 1984."},{"key":"e_1_2_1_43_2","first-page":"487A","volume":"32","author":"Tanabe A","year":"1984","journal-title":"Clin Res"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.240280408","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.240280408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T15:50:44Z","timestamp":1697817044000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.240280408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,1]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1985,1]]}},"alternative-id":["10.1002\/jcb.240280408"],"URL":"https:\/\/doi.org\/10.1002\/jcb.240280408","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,1]]}}}