{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:02:01Z","timestamp":1770966121634,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,2,19]],"date-time":"2004-02-19T00:00:00Z","timestamp":1077148800000},"content-version":"vor","delay-in-days":6138,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[1987,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>WEHI\u2010274 is a monocytic leukemia that arose in a BALB\/c mouse infected with Abelson murine leukemia virus. A series of subclones were derived from early passages of this tumor. Three subsets of these leukemogenic subclones were identified. Two subsets demonstrated autostimulatory patterns of growth. This was due to the ectopic production of the T\u2010cell lymphokine the panspecific hemopoietin IL\u20103 in one case and of the T\u2010cell lymphokine granulocyte\u2010macro\u2010phage colony\u2010stimulating factor (GM\u2010CSF) in the other. The third type of subclone did not secrete any autostimulatory growth factor. In the subclone producing IL\u20103, one copy of IL\u20103 gene was rearranged and abnormal IL\u20103 RNA transcripts were present in the nucleus. Subclones producing GM\u2010CSF also contained abnormal GM\u2010CSF RNA transcripts, although no rearrangement of the GM\u2010CSF gene was detected. All three sets of subclones shared a common rearrangement of one c\u2010<jats:italic>myb<\/jats:italic> oncogene, suggesting that they share a common ancestor. These results suggest that initiation or progression of leukemogenic behavior in this abnormal clone occurred in three different ways, two of which involved autostimulation by the ectopic activation of T\u2010cell lymphokine genes.<\/jats:p>","DOI":"10.1002\/jcb.240340106","type":"journal-article","created":{"date-parts":[[2004,12,30]],"date-time":"2004-12-30T15:22:47Z","timestamp":1104420167000},"page":"39-46","source":"Crossref","is-referenced-by-count":11,"title":["Autostimulatory mechanisms in myeloid leukemogenesis"],"prefix":"10.1002","volume":"34","author":[{"given":"J. W.","family":"Schrader","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. B.","family":"Leslie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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