{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T19:30:16Z","timestamp":1698089416871},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,2,19]],"date-time":"2004-02-19T00:00:00Z","timestamp":1077148800000},"content-version":"vor","delay-in-days":6138,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[1987,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Activities of angiotensin\u2010converting enzyme (ACE), other proteinases, and eosinophil chemotactic factor (ECF\u2010G) are known to be elevated in hepatic hypersensitivity granulomas of thymus intact (nu\/+) mice after <jats:italic>Schistosoma mansoni<\/jats:italic> infection. The enzyme activities also increase, but to a lesser degree in hepatic granulomas of athymic nude (nu\/nu) mice, and ECF\u2010G is not detectable. In this study isolated hepatic granulomas from nu\/+ mice were grafted into the skin of uninfected nu\/nu mice, and changes in those cellular functions were determined to examine whether the newly formed granulomas by recipient nu\/nu cells acquire the functional activities as well as the histological appearance of nu\/+ granulomas. ACE and ECF\u2010G rapidly disappeared from grafted sites during the first 5 days, corresponding to loss of nu\/+ cells from the graft. Reduction in activities of arylsulfatases, lysozyme, and acid phosphatase also occurred, but to a lesser extent. Recovery of ACE and ECF\u2010G activities to the levels seen in nu\/+ hepatic granulomas was observed by 14 days after grafting when nu\/nu cells had accumulated in the grafts and formed new granulomas. Other enzymes increased to approximately half the levels seen in grafted donor granulomas. Circulating eosinophilia also increased. The findings indicate that nu\/nu cells that accumulated in the skin grafts not only morphologically mimicked nu\/+ type granulomas but also demonstrated nu\/+ levels of cellular function. Analysis of skin granulomas developing in nu\/+ mice after grafting of nu\/+ hepatic granulomas showed the similar histology and enzymatic changes, whereas the skin sites inoculated with purified schistosome eggs alone caused neither significant histological changes nor elevation of ACE activity.<\/jats:p>","DOI":"10.1002\/jcb.240340108","type":"journal-article","created":{"date-parts":[[2004,12,30]],"date-time":"2004-12-30T15:22:47Z","timestamp":1104420167000},"page":"61-69","source":"Crossref","is-referenced-by-count":4,"title":["Induction of granuloma\u2010dependent angiotensin\u2010converting enzyme and eosinophil chemotactic factor in the skin of athymic nude 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