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Both interferons and TPA down\u2010regulate expression of the c\u2010myc oncogene in these cells. Although TPA can mimic the effect of interferon on cell differentiation, it does not induce 2\u20325\u2032 oligoadenylate synthetase or the interferon\u2010sensitive mRNAs, 6\u201316 or 9\u201327. Thus chronic stimulation of protein kinase C by TPA cannot mimic all of the effects of interferon treatment on gene expression. Inhibition of ADP\u2010ribosyl transferase activity by 3\u2010methoxybenzamide impairs interferon\u2010 or TPA\u2010induced differentiation of Daudi cells. This agent induces a higher level of c\u2010myc mRNA in the cells and stimulates the incorporation of [<jats:sup>3<\/jats:sup>H]thymidine into DNA; although these effects are partially counteracted by interferon or TPA treatment, the elevated expression of the c\u2010myc gene may be sufficient to prevent terminal differentiation and allow cell proliferation to continue.<\/jats:p>","DOI":"10.1002\/jcb.240380404","type":"journal-article","created":{"date-parts":[[2004,12,30]],"date-time":"2004-12-30T15:41:36Z","timestamp":1104421296000},"page":"251-259","source":"Crossref","is-referenced-by-count":13,"title":["Relationship of cellular oncogene expression to inhibition of growth and induction of differentiation of Daudi cells by interferons or TPA"],"prefix":"10.1002","volume":"38","author":[{"given":"Michael J.","family":"Clemens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivienne 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