{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T09:08:02Z","timestamp":1706260082506},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,2,19]],"date-time":"2004-02-19T00:00:00Z","timestamp":1077148800000},"content-version":"vor","delay-in-days":4919,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The nocturnal pattern of Syrian hamster pineal melatonin synthesis is characterized by a 6\u20138 h lag period, followed by a late\u2010night, short\u2010duration peak in both N\u2010acetyltransferase (NAT) activity and melatonin content. Administration of cycloheximide (20 mg\/kg body weight) given either at the time of lights out or 4 h into the dark phase to Syrian hamsters blocked the nocturnal increase in both pineal NAT activity and melatonin content. Actinomycin D (5 mg\/kg body weight) prevented the nocturnal increase in both constituents only when it was administered at darkness onset, being significantly less effective when injected after 4 h of dark exposure. Reinduction of melatonin production by isoproterenol (2 mg\/kg body weight) administration to acutely light\u2010exposed animals during late darkness was prevented by cycloheximide, but not by actinomycin D administration. The results suggest that whereas Syrian hamster pineal melatonin production requires protein synthesis both early and late in the dark phase, the transcription of a putative NAT\u2010related mRNA, which occurs only during the early night, seems to determine the lag period in melatonin synthesis and pineal responsiveness to \u03b2\u2010adrenergic receptor agonist stimulation.<\/jats:p>","DOI":"10.1002\/jcb.240440105","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T20:31:17Z","timestamp":1117312277000},"page":"55-60","source":"Crossref","is-referenced-by-count":9,"title":["mRNA transcription determines the lag period for the induction of pineal melatonin synthesis in the Syrian hamster pineal gland"],"prefix":"10.1002","volume":"44","author":[{"given":"Aldo","family":"Gonzalez\u2010Brito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maureen 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