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Because 1,25\u2010dihydroxy vitamin D<jats:sub>3<\/jats:sub> inhibits epidermal proliferation and promotes epidermal differentiation, it has been introduced for the treatment of psoriasis vulgaris. In addition to 1,25\u2010(OH)<jats:sub>2<\/jats:sub>\u2010D<jats:sub>3<\/jats:sub>, synthetic vitamin D<jats:sub>3<\/jats:sub> analogues have undergone clinical evaluation. Calcipotriol (INN) (calcipotriene [USAN]) has been studied most extensively. Compared with 1,25\u2010(OH)<jats:sub>2<\/jats:sub>\u2010D<jats:sub>3<\/jats:sub>, calcipotriol is about 200 times less potent in its effects on calcium metabolism, although similar in receptor affinity. Topical calcipotriol 50 \u03bcg\/g applied twice daily is efficacious and safe for the treatment of psoriasis. Because topical calcipotriol is slightly more efficacious than betamethasone 17\u2010valerate and dithranol, calcipotriol should be considered a first line drug in the management of psoriasis. 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