{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:47:45Z","timestamp":1783633665538,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"S17F","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":8278,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Cell. Biochem."],"published-print":{"date-parts":[[1993]]},"DOI":"10.1002\/jcb.240531007","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T21:25:02Z","timestamp":1117315502000},"page":"37-48","source":"Crossref","is-referenced-by-count":43,"title":["Intraepithelial neoplasia, surrogate endpoint biomarkers, and cancer chemoprevention"],"prefix":"10.1002","volume":"53","author":[{"given":"Charles W.","family":"Boone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary J.","family":"Kelloff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"10.1002\/jcb.240531007-BIB1","first-page":"1651","volume":"52","author":"Boone","year":"1992","journal-title":"Cancer Res"},{"key":"10.1002\/jcb.240531007-BIB2","first-page":"194","volume":"30","author":"McClellan","year":"1989","journal-title":"Proc Am Assoc Cancer Res"},{"key":"10.1002\/jcb.240531007-BIB3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0046-8177(91)90163-J","volume":"22","author":"Roncucci","year":"1991","journal-title":"Hum Pathol"},{"key":"10.1002\/jcb.240531007-BIB4","first-page":"291","volume-title":"Pathological Basis of Disease","author":"Robbins","year":"1984","unstructured":": \u201cPathological Basis of Disease.\u201d Philadelphia: W.B. Saunders Company, 1984, p 291."},{"key":"10.1002\/jcb.240531007-BIB5","first-page":"788","volume-title":"Modern Pharmacology","author":"Craig","year":"1986","unstructured":"(eds): \u201cModern Pharmacology.\u201d Boston: Little, Brown, and Company, 2nd ed, 1986, p 788."},{"key":"10.1002\/jcb.240531007-BIB6","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/1097-0142(19890115)63:2<386::AID-CNCR2820630231>3.0.CO;2-6","volume":"63","author":"Rigel","year":"1989","journal-title":"Cancer"},{"key":"10.1002\/jcb.240531007-BIB7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0065-230X(08)60438-8","volume":"50","author":"Woodruff","year":"1988","journal-title":"Adv Cancer Res"},{"key":"10.1002\/jcb.240531007-BIB8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jcp.35.1.1","volume":"35","author":"Buckley","year":"1982","journal-title":"J Clin Pathol"},{"key":"10.1002\/jcb.240531007-BIB9","first-page":"225","volume-title":"Haines and Taylor Obstetric and Gynecologic Pathology","author":"Anderson","year":"1987","unstructured":": Premalignant and malignant diseases of the cervix. In (ed): \u201cHaines and Taylor Obstetric and Gynecologic Pathology.\u201d New York: Churchill Livingston, 1987, pp 225-277."},{"key":"10.1002\/jcb.240531007-BIB10","first-page":"9","volume-title":"Neoplastic Development","volume":"2","author":"Foulds","year":"1975","unstructured":": \u201cNeoplastic Development.\u201d New York: Academic Press, Vol 2, 1975, pp 9-10."},{"key":"10.1002\/jcb.240531007-BIB11","first-page":"413","volume-title":"Chromosome Mutation and Neoplasia","author":"Nowell","year":"1983","unstructured":": Tumor progression and clonal evolution: The role of genetic instability. In (ed): \u201cChromosome Mutation and Neoplasia.\u201d New York: Alan R. Liss, Inc., 1983, pp 413-432."},{"key":"10.1002\/jcb.240531007-BIB12","first-page":"385","volume":"5","author":"Glucksmann","year":"1945","journal-title":"Cancer Res"},{"key":"10.1002\/jcb.240531007-BIB13","series-title":"UICC Monograp","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/978-3-642-87898-5_9","volume-title":"Potential Carcinogenic Hazards from Drugs","volume":"7","author":"Druckrey","year":"1967","unstructured":": Quantitative aspects in chemical carcinogenesis. In (ed): \u201cPotential Carcinogenic Hazards from Drugs.\u201d UICC Monograph Series Vol 7, New York: Springer-Verlag, 1967, pp 60-78."},{"key":"10.1002\/jcb.240531007-BIB14","first-page":"337","volume-title":"Carcinogens: Identification and Mechanisms of Action","author":"Scherer","year":"1979","unstructured":": Multi-hit kinetics of tumor cell formation and risk assessment of low doses of carcinogen. In (eds): \u201cCarcinogens: Identification and Mechanisms of Action.\u201d New York: Raven Press, 1979, pp 337-364."},{"key":"10.1002\/jcb.240531007-BIB15","volume-title":"Mechanisms of Tumor Promotion, Vol 1: \u201cTumor Promotion in Internal Organs\u201d","author":"Burns","year":"1983","unstructured":": Cancer progression in mouse skin. \u201cMechanisms of Tumor Promotion, Vol 1: \u201cTumor Promotion in Internal Organs\u201d.\u201d Boca Raton: CRC Press, Inc., 1983."},{"key":"10.1002\/jcb.240531007-BIB16","first-page":"303","volume":"21","author":"Ames","year":"1990","journal-title":"Princess Takamatsu Symp"},{"key":"10.1002\/jcb.240531007-BIB17","first-page":"253","volume":"9","author":"Gauvain","year":"1987","journal-title":"Anal Quant Cytol Histol"},{"key":"10.1002\/jcb.240531007-BIB18","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1002\/1097-0142(19920515)69:10<2454::AID-CNCR2820691012>3.0.CO;2-K","volume":"69","author":"Cagle","year":"1992","journal-title":"Cancer"},{"key":"10.1002\/jcb.240531007-BIB19","first-page":"440","volume":"11","author":"Hufnagle","year":"1989","journal-title":"Anal Quant Cytol Histol"},{"key":"10.1002\/jcb.240531007-BIB20","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/1097-0142(19920115)69:2<511::AID-CNCR2820690239>3.0.CO;2-3","volume":"69","author":"Mohler","year":"1992","journal-title":"Cancer"},{"key":"10.1002\/jcb.240531007-BIB21","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0030-4220(90)90297-6","volume":"69","author":"Abdel-Salem","year":"1990","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1002\/jcb.240531007-BIB22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1136\/jcp.43.2.157","volume":"43","author":"van Diest","year":"1990","journal-title":"J Clin Path"},{"key":"10.1002\/jcb.240531007-BIB23","first-page":"177","volume":"11","author":"Bocking","year":"1989","journal-title":"Anal Quant Cytol Histol"},{"key":"10.1002\/jcb.240531007-BIB24","first-page":"98","volume":"12","author":"Teplitz","year":"1990","journal-title":"Anal Quant Cytol Histol"},{"key":"10.1002\/jcb.240531007-BIB25","first-page":"263","volume":"9","author":"Erdhardt","year":"1987","journal-title":"Anal Quant Cytol Histol"},{"key":"10.1002\/jcb.240531007-BIB26","first-page":"215","volume":"1","author":"Del Bino","year":"1989","journal-title":"Anal Cell Path"},{"key":"10.1002\/jcb.240531007-BIB27","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/BF00315851","volume":"93","author":"Hougard","year":"1990","journal-title":"Histochem"},{"key":"10.1002\/jcb.240531007-BIB28","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1016\/S0021-9258(18)42912-2","volume":"267","author":"Jonges","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1002\/jcb.240531007-BIB29","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/BF01753353","volume":"21","author":"Pette","year":"1989","journal-title":"Histochem J"},{"key":"10.1002\/jcb.240531007-BIB30","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0344-0338(88)80131-6","volume":"183","author":"Stal","year":"1988","journal-title":"Path Res Pract"},{"key":"10.1002\/jcb.240531007-BIB31","first-page":"339a","volume":"147","author":"Rao","year":"1992","journal-title":"J Urol"},{"key":"10.1002\/jcb.240531007-BIB32","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/BF01753363","volume":"21","author":"Van Duijn","year":"1989","journal-title":"Histochem J"},{"key":"10.1002\/jcb.240531007-BIB33","first-page":"32","volume":"39","author":"Champelovier","year":"1990","journal-title":"J Histochem Cytochem"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.240531007","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/jcb.240531007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,11]],"date-time":"2021-07-11T09:44:44Z","timestamp":1625996684000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.240531007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993]]},"references-count":33,"journal-issue":{"issue":"S17F","published-print":{"date-parts":[[1993]]}},"URL":"https:\/\/doi.org\/10.1002\/jcb.240531007","relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993]]}}}