{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:45:15Z","timestamp":1789767915779,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,2,19]],"date-time":"2004-02-19T00:00:00Z","timestamp":1077148800000},"content-version":"vor","delay-in-days":3367,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[1994,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The expression of the human myeloid cell nuclear differentiation antigen (MNDA) was observed specifically in cells of the granulocyte\u2010macrophage lineage in our earlier reports. The specificity of MNDA expression for cells in the granulocyte\u2010macrophage lineage was reexamined in cell line established from patients with philadelphia chromosome\u2010positive chroni myeloid leukemia. Cell lines that expressed MNDA exhibited myeloid cell features and granulocyte or monocyte defferentiation could be induced in vitro, while cell lines exhibiting properties of very early stage cells of multipotential cells ded not express MNDA. Cells orginating from cases of burkitt's lymphoma were negative. By contrast, three Iymphoblastoid cell lines (immortalized in vitro with Epstein\u2010Barr virus) were weakly positive and MNDA was up\u2010regulated by interferon\u2010\u03b1 (IFN\u2010\u03b1) treatment. As we reported previously, MNDA mRNA level in adherent monocytes is elevated by IFN\u2010\u03b1; in this study, we further assessed MNDA expression in in vitro monocyte\u2010derived macrophages. Three addditional agents (endotoxin, phytohemagglutinin, and photbol ester) and other conditions that affect function, cutokine production, defferentiation, and\/of growth of monocytes were examined for their ability to alter MNDA expression. The results varied with the agent, cell type, and stage of differentiation. Changes in MNDA expression occurred slowly (hours to days), suggesting that MNDA could mediate changes realized over a long period. The results also reveal a discordance in certain MNDA Positiva cells between steady\u2010state levels of changes in levels of protein and mRNA indicating that the regulation of MNDA expression occurs at more than one point. Changes in MNDA expression are consistent with a role in opposing macrophage defferentiation and activation of monocytes\/macrophages.<\/jats:p>","DOI":"10.1002\/jcb.240560417","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T21:54:43Z","timestamp":1117317283000},"page":"559-567","source":"Crossref","is-referenced-by-count":35,"title":["Regulation and specificity of MNDA expression in monocytes, macrophages, and leukemia\/B lymophoma cell lines"],"prefix":"10.1002","volume":"56","author":[{"given":"R. C.","family":"Briggs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Y.","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. L.","family":"Dworkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Briggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. N.","family":"Dessypris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,2,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1128\/jvi.68.6.3491-3498.1994","article-title":"Epstein\u2010Barr virus nuclear antigen EBNA3C\/6 expression maintains the level of latent membrane protein 1 in G1\u2010arrested cells","volume":"68","author":"Allday MJ","year":"1994","journal-title":"J Virol"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-74-3-361"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.47.6.490"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.5.1537"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(84)90085-6"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1128\/jvi.68.2.1200-1203.1994","article-title":"Different activation of Epstein\u2010Barr virus immediate\u2010early and early genes in Burkitt lymphoma cells and lymphoblastoid cell lines","volume":"68","author":"Bogedain C","year":"1994","journal-title":"J Virol"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240540208"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1182\/blood.V83.8.2153.2153","article-title":"The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon\u2010inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells","volume":"83","author":"Briggs RC","year":"1994","journal-title":"Blood"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"12487","DOI":"10.1016\/S0021-9258(18)98925-8","article-title":"Low basal transcription of genes for tissue\u2010specific collagens by fibroblasts and lymphoblastoid cells","volume":"266","author":"Chan D","year":"1991","journal-title":"J Biol Chem"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.8.2617"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.44.2.101"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.1994.14.11"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.16.7613"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(90)90182-9"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0934-8832(11)80071-5"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(83)80013-8"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"4726","DOI":"10.1016\/S0021-9258(17)38562-9","article-title":"Properties of a nuclear protein marker of human myeloid cell differentiation","volume":"261","author":"Golderger A","year":"1986","journal-title":"J Biol Chem"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0268-960X(93)90008-R"},{"key":"e_1_2_1_20_1","first-page":"513","volume-title":"UCLA Symposia on Molecular and Cellular Biology: Normal and Neoplastic Hematopoiesis.","author":"Keating G","year":"1983"},{"key":"e_1_2_1_21_1","first-page":"3087","article-title":"Effects of 1\u03b1,25\u2010dihydroxyvitamin D3 on the human chronic myelogenous leukemia cell line RWLeu\u20104","volume":"50","author":"Lasky SR","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.4049\/jimmunol.152.1.241","article-title":"Production of IL\u20108 and monocyte chemotactic peptide\u20101 by peripheral blood monocytes","volume":"152","author":"Liebler JM","year":"1994","journal-title":"J Immunol"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-166-41106"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1994.tb03337.x"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(93)90128-N"},{"key":"e_1_2_1_26_1","first-page":"447","article-title":"Establishment of a Ph\u2010positive human cell line (BV173)","volume":"70","author":"Pegoraro L","year":"1983","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(93)90008-P"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2565599"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.53.5.563"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.3.776.776"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00218044"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116171"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.240560417","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.240560417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T04:58:41Z","timestamp":1698123521000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.240560417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,12]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,12]]}},"alternative-id":["10.1002\/jcb.240560417"],"URL":"https:\/\/doi.org\/10.1002\/jcb.240560417","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,12]]}}}