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The reduced liver weight by partial hepatectomy (about 70%) was completely restored at 3 days after surgery. Regenerating liver significantly increased calcium content. Liver regucalcin mRNA levels clearly increased 1\u20135 days after hepatectomy, in comparison with that of sham\u2010operated rats, although the increase was not seen 12 hr after the surgery. Increased regucalcin mRNA levels in regenerating liver were appreciably reduced by single intraperitoneal administration of actinomycin D (100 \u03bcg\/100 g body weight), an inhibitor of transcriptional process. Moreover, the increased regucalcin mRNA levels by hepatectomy was weakened by a single intraperitoneal administration of trifluoperazine (2.5 mg\/100 g), an inhibitor of Ca<jats:sup>2+<\/jats:sup>\/calmodulin. These findings demonstrate that the expression of hepatic regucalcin mRNA is enhanced in regenerating rat liver.<\/jats:p>","DOI":"10.1002\/jcb.240570203","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T22:04:29Z","timestamp":1117317869000},"page":"185-190","source":"Crossref","is-referenced-by-count":34,"title":["Enhanced expression of calcium\u2010binding protein regucalcin mRNA in regenerating rat liver"],"prefix":"10.1002","volume":"57","author":[{"given":"Masayoshi","family":"Yamaguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Kanayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,2,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041530213"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(80)90849-9"},{"key":"e_1_2_1_4_1","first-page":"18","article-title":"Calmodulin plays a pivotal role in cellular regulation","volume":"202","author":"Cheung WY","year":"1980","journal-title":"Science"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"e_1_2_1_6_1","first-page":"186","article-title":"Experimental pathology of the liver. 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