{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:19:13Z","timestamp":1758925153718},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T00:00:00Z","timestamp":1347926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The highly active antiretroviral therapy (HAART) can cause a metabolic syndrome consisting of lipodystropy\/lipoatrophy, dyslipidemia, and type 2 diabetes mellitus with an increased cardiovascular risk. The pathogenetic bases of HAART\u2010associated lipodystrophy are poorly known. A genetic screen was used to evaluate proteins that are modulated in HIV\u20101\u2010infected patients with or without lipodystrophy syndrome, that are routinely treated with HAART regimens. The most significant modulation was represented by FAP48 expression. Stable over\u2010expression of FAP48 was able to alter, in vitro, adipogenesis, acting both on calcineurin and glucocorticoid pathways. Finally, we demonstrated that FAP48 over\u2010expression was able to influence the capacity of some HIV drugs, Saquinavir and Efavirenz, but not Stavudine, Amprenavir, and Indinavir to inhibit adipocyte formation. In conclusion, this molecule could be a potential target for novel therapeutic approaches to the HAART related lipodystrophy in HIV patients. J. Cell. Biochem. 113: 3446\u20133454, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jcb.24221","type":"journal-article","created":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T15:07:25Z","timestamp":1339081645000},"page":"3446-3454","source":"Crossref","is-referenced-by-count":9,"title":["Role of FAP48 in HIV\u2010associated lipodystrophy"],"prefix":"10.1002","volume":"113","author":[{"given":"Vincenzo","family":"Esposito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucrezia","family":"Manente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Lucariello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelica","family":"Perna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosaria","family":"Viglietti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Gargiulo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Parrella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Parrella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Baldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Chirianni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mjt.0000162013.66614.16"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5308.1930"},{"key":"e_1_2_5_4_1","first-page":"26","article-title":"The long\u2010term consequences of antiretroviral therapy: A review","volume":"11","author":"Boyd M","year":"2006","journal-title":"J HIV Ther"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06940.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.51.32923"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5343.1638"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/357695a0"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20566"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.18.13571"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2595372"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2008.09.016"},{"key":"e_1_2_5_13_1","first-page":"237","article-title":"Comparative transcriptional profiling in HIV\u2010infected patients using human stress arrays: Clues to metabolic syndrome","volume":"26","author":"Esposito V","year":"2012","journal-title":"In Vivo"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/352803a0"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/360682a0"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90123-G"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1993.tb18189.x"},{"key":"e_1_2_5_18_1","unstructured":"GalliM PoloM Saint\u2010MarcT WalliR.2000. 2nd International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV. 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