{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:55:22Z","timestamp":1791298522547,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,14]],"date-time":"2012-11-14T00:00:00Z","timestamp":1352851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The regulation of trophoblast apoptosis is essential for normal placentation, and increased placental trophoblast cell apoptosis is the cause of pathologies such as intrauterine growth retardation (IUGR) and pre\u2010eclampsia. X\u2010linked inhibitor of apoptosis (XIAP) is expressed in trophoblasts, but little is known about the role of XIAP in placental development. In the present study, the function of XIAP in the placenta and in HTR\u20108\/SVneo trophoblasts under hypoxic conditions was examined. In addition, the correlation between XIAP and immortalization\u2010upregulated protein\u20102 (IMUP\u20102) was demonstrated in HTR\u20108\/SVneo trophoblasts under hypoxia, based on a previous study showing that increased IMUP\u20102 induces trophoblast apoptosis and pre\u2010eclampsia. XIAP was downregulated in pre\u2010eclamptic placentas (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). In HTR\u20108\/SVneo trophoblasts, XIAP expression was decreased and the expression of apoptosis\u2010related genes was increased in response to hypoxia. Ectopic expression of hypoxia inducible factor (HIF)\u20101\u03b1 in HRT\u20108 SV\/neo cells induced the nuclear translocation of XIAP and alterations of XIAP protein stability. Furthermore, hypoxia induced nuclear translocated XIAP co\u2010localized with upregulated IMUP\u20102 in trophoblast nuclei, and the interaction between XIAP and IMUP\u20102 induced apoptosis in HRT\u20108 SV\/neo cells. The present results suggest that hypoxia\u2010induced down\u2010regulation of XIAP mediates apoptosis in trophoblasts through interaction with increased IMUP\u20102, and that this mechanism underlies the pathogenesis of pre\u2010eclampsia. J. Cell. Biochem. 114: 89\u201398, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jcb.24304","type":"journal-article","created":{"date-parts":[[2012,8,6]],"date-time":"2012-08-06T14:28:46Z","timestamp":1344263326000},"page":"89-98","source":"Crossref","is-referenced-by-count":16,"title":["Hypoxia\u2010induced downregulation of XIAP in trophoblasts mediates apoptosis via interaction with IMUP\u20102: Implications for placental development during pre\u2010eclampsia"],"prefix":"10.1002","volume":"114","author":[{"given":"Su Yeon","family":"Jeon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Jung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu\u2010Hwan","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Hyun","family":"Cha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Kyeoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Wan","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Ki","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2002.0815"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400795"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod64.4.1264"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/35080103"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.01.011"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.03.005"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004180050311"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.07.039"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.119176"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22568"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(00)00423-1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202569"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/plac.1999.0450"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-5-6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2006.00589.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-007-0092-6"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0035"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00033.2008"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2007.11.015"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102415200"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20071249"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2001-2-7-reviews3009"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.24304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.24304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T01:00:27Z","timestamp":1697677227000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.24304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,14]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1002\/jcb.24304"],"URL":"https:\/\/doi.org\/10.1002\/jcb.24304","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,14]]}}}