{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:27:15Z","timestamp":1790501235683,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,22]],"date-time":"2013-01-22T00:00:00Z","timestamp":1358812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    (\n                    <jats:italic>H. pylori<\/jats:italic>\n                    ) infection causes chronic gastritis and peptic ulceration and is the strongest risk factor for the development of gastric cancer. The pathogenesis of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    is believed to be associated with infection\u2010initiated chronic gastritis, which is characterized by enhanced expression of many inflammatory genes.\n                    <jats:italic>H. pylori<\/jats:italic>\n                    utilizes various virulence factors, targeting different cellular proteins, to modulate the host inflammatory response. In this review, we explore the many different ways by which\n                    <jats:italic>H. pylori<\/jats:italic>\n                    initiates inflammation, leveling many \u201chits\u201d on the gastric mucosa which can lead to the development of cancer. We also discuss some recent findings in understanding the pathogen\u2010host interactions and the role of transcription factor NF\u2010\u03baB in\n                    <jats:italic>H. pylori<\/jats:italic>\n                    \u2010induced inflammation. J. Cell. Biochem. 114: 491\u2013497, 2013. \u00a9 2012 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/jcb.24389","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T09:59:23Z","timestamp":1347011963000},"page":"491-497","source":"Crossref","is-referenced-by-count":190,"title":["Role of the\n                    <i>Helicobacter pylori<\/i>\n                    \u2010Induced inflammatory response in the development of gastric cancer"],"prefix":"10.1002","volume":"114","author":[{"given":"Acacia","family":"Lamb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin\u2010Feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210413"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2009.06.020"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900664"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2010.08.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04046-0"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199705000-00008"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir547"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1106200108"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-010-0118-1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1368"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-0828-y"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i35.3971"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02098-07"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2007.00258.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.6.2213-2220.1995"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.076976"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029007"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102111"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.3.347"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2009.01421.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1999.tb01517.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2007.12.003"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.01.020"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.8.56"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.2.1406"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3111"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1703"},{"key":"e_1_2_9_30_1","first-page":"190","article-title":"Toll\u2010like receptor 4 regulates gastric pit cell responses to Helicobacter pylori infection","volume":"48","author":"Kawahara T","year":"2001","journal-title":"J Med Invest"},{"key":"e_1_2_9_31_1","first-page":"197","article-title":"Helicobacter pylori infection is an independent risk factor for Runx3 methylation in gastric cancer","volume":"19","author":"Kitajima Y","year":"2008","journal-title":"Oncol Rep"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2009.210"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.1.2.11587"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.06.017"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105381200"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.11.6446-6454.2004"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001574-200001000-00005"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200203)32:3<671::AID-IMMU671>3.0.CO;2-5"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.04.005"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210251"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01794-06"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05109-11"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.11.7162"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(02)02375-4"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/stke.2772005pe14"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.3.1312"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.194795"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2040"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1780"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06817.x"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.177"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208969"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.11.010"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2009.00683.x"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.304"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22964"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.10.036"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1131"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/35085597"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02380-06"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2010.154"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.130079797"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000387"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.55"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00287.2001"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.24389","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.24389","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T19:19:00Z","timestamp":1696879140000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.24389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,22]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1002\/jcb.24389"],"URL":"https:\/\/doi.org\/10.1002\/jcb.24389","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,22]]}}}