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This review will discuss pre\u2010clinical studies which have utilized stem or progenitor cells for transplantation therapy using HD animal models. In several studies, neural stem and progenitor cells used as allotransplants and xenografts have been shown to be capable of surviving transplantation and differentiating into mature GABAergic neurons, resulting in behavioral improvements. Beneficial effects have also been reported for transplantation of stem cells derived from non\u2010neural tissue, for example, mesenchymal\u2010 and adipose\u2010derived stem cells, which have mainly been attributed to their secretion of growth and neurotrophic factors. Finally, we review studies using stem cells genetically engineered to over\u2010express defined neurotrophic factors. While these studies prove the potential of stem cells for transplantation therapy in HD, it also becomes clear that technical and ethical issues regarding the availability of stem cells must be solved before human trials can be conducted. J. Cell. Biochem. 114: 754\u2013763, 2013. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jcb.24432","type":"journal-article","created":{"date-parts":[[2012,10,23]],"date-time":"2012-10-23T17:17:47Z","timestamp":1351012667000},"page":"754-763","source":"Crossref","is-referenced-by-count":46,"title":["Stem cell\u2010based therapy for Huntington's disease"],"prefix":"10.1002","volume":"114","author":[{"given":"Christof","family":"Maucksch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena M.","family":"Vazey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee 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