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In this study, we first found that MSCs promoted prostate cancer (PCa) tumor growth in vivo and cell proliferation in vitro by using PCs cell strain RM\u20101. Both exogenous and endogenous MSCs could be recruited into the tumor microenvironment by using bone\u2010marrow transplantation model. We further demonstrated that PDGF\u2010BB produced by RM\u20101 cell promoted MSCs proliferation in vivo and in vitro, which was abrogated by Si\u2010RNA specific to PDGF\u2010BB. And inflammatory cytokines, such as interferon gamma, tumor necrosis factor alpha, and anti\u2010inflammatory cytokine transformation growth factor alpha, further increased the ability of RM\u20101 to produce PDGF\u2010BB. Overall, PCa cells produced PDGF\u2010BB favors the proliferation of MSCs, which may elicit immunosuppressive function and enable PCa cells to escape from the immunity surveillance in tumor inflammatory microenvironment. J. Cell. 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