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In the present study, vibrissa hair follicles, including their sensory nerve stump, were excised from transgenic mice in which the nestin promoter drives green fluorescent protein (ND\u2010GFP mice), and were placed in 3D histoculture supported by Gelfoam\u00ae. \u03b2\u2010III tubulin\u2010positive fibers, consisting of ND\u2010GFP\u2010expressing cells, extended up to 500\u2009\u00b5m from the whisker nerve stump in histoculture. The growing fibers had growth cones on their tips expressing F\u2010actin. These findings indicate that \u03b2\u2010III tubulin\u2010positive fibers elongating from the whisker follicle sensory nerve stump were growing axons. The growing whisker sensory nerve was highly enriched in ND\u2010GFP cells which appeared to play a major role in its elongation and interaction with other nerves in 3D culture, including the sciatic nerve, the trigeminal nerve, and the trigeminal nerve ganglion. The results of the present report suggest a major function of the nestin\u2010expressing stem cells in the hair follicle is for growth of the follicle sensory nerve. J. Cell. Biochem. 114: 1674\u20131684, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jcb.24509","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T15:25:41Z","timestamp":1361892341000},"page":"1674-1684","source":"Crossref","is-referenced-by-count":51,"title":["The role of hair follicle nestin\u2010expressing stem cells during whisker sensory\u2010nerve growth in long\u2010term 3D 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