{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:21:49Z","timestamp":1715599309155},"reference-count":59,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label \/><jats:p>The role that the induction of cardiac ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, by beta\u2010adrenergic agents may have in heart hypertrophy is a controversial issue. Besides, the signaling pathways related to cardiac ODC regulation have not been fully elucidated. Here we show that in Balb C mice the stimulation of cardiac ODC activity by adrenergic agents was mainly mediated by \u03b2<jats:sub>2<\/jats:sub>\u2010adrenergic receptors, and that this induction was lower in the hypertrophic heart. Interestingly, this stimulation was abolished by the L\u2010calcium channel antagonists verapamil and nifedipine. In addition, whereas the treatment with \u03b2<jats:sub>2<\/jats:sub>\u2010adrenergic agents was associated to both the increases in ODC, ODC\u2010antizyme inhibitor 1 (AZIN1), c\u2010fos and c\u2010myc mRNA levels and the phosphorylation of CREB and MAP kinases ERK1 and ERK2 (ERK1\/2), the co\u2010treatment with L\u2010calcium channel blockers differentially prevented most of these changes. These results suggest that the stimulation of cardiac ODC by \u03b2<jats:sub>2<\/jats:sub>\u2010adrenergic agents is associated with the activation of MAP kinases through the participation of L\u2010calcium channels, and that by itself p\u2010CREB does not appear to be sufficient for the transcriptional activation of ODC. In addition, post\u2010translational mechanisms related with the induction of AZIN1 appear to be related to the increase of cardiac ODC activity. J. Cell. Biochem. 114: 1978\u20131986, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.24540","type":"journal-article","created":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T13:14:35Z","timestamp":1363785275000},"page":"1978-1986","source":"Crossref","is-referenced-by-count":6,"title":["The induction of cardiac ornithine decarboxylase by \u03b2<sub>2<\/sub>\u2010adrenergic agents is associated with calcium channels and phosphorylation of ERK1\/2"],"prefix":"10.1002","volume":"114","author":[{"given":"Andr\u00e9s J.","family":"L\u00f3pez\u2010Contreras","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Biochemistry and Molecular Biology B and Immunology University of Murcia Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Eugenia","family":"de la Morena","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Biochemistry and Molecular Biology B and Immunology 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