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Typically, FBP1 could active the translation of p27kip1 (p27) and participate in tumor growth. However, the expression and roles of FBP1 in peripheral system lesions and repair are still unknown. In our study, we found that FBP1 protein levels was relatively higher in the normal sciatic nerves, significantly decreased and reached a minimal level at Day 3, and then returned to the normal level at 4 weeks. Spatially, we observed that FBP1 had a major colocation in Schwann cells and FBP1 was connected with Ki\u201067 and Oct\u20106. In vitro, we detected the decreased level of FBP1 and p27 in the TNF\u2010\u03b1\u2010induced Schwann cells proliferation model, while increased expression in cAMP\u2010induced Schwann cells differentiation system. Specially, FBP1\u2010specific siRNA\u2010transfected SCs did not show fine and longer morphological change after cAMP treatment and had a decreased motility compared with normal. At 3 days after cAMP treatment and SC\/neuron co\u2010cultures, p27 was transported to cytoplasm to form CDK4\/6\u2010p27 to participate in SCs differentiation. In conclusion, we speculated that FBP1 and p27 were involved in SCs proliferation and the following differentiation in the sciatic nerve after crush by transporting p27 from nucleus to cytoplasm. J. Cell. Biochem. 115: 130\u2013140, 2014. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.24640","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T13:18:52Z","timestamp":1376313532000},"page":"130-140","source":"Crossref","is-referenced-by-count":14,"title":["FBP1 and p27kip1 Expression After Sciatic Nerve Injury: Implications for Schwann Cells Proliferation and Differentiation"],"prefix":"10.1002","volume":"115","author":[{"given":"Li","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Affiliated Jiangyin Hospital of Nantong University Nantong Jiangsu 226001, People's Republic of China"},{"name":"Department of Immunology, Medical College Nantong University Nantong Jiangsu 226001, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Affiliated Mental Health 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