{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T01:47:06Z","timestamp":1772848026051,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,13]],"date-time":"2013-12-13T00:00:00Z","timestamp":1386892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81000036"],"award-info":[{"award-number":["81000036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30900524"],"award-info":[{"award-number":["30900524"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30972954"],"award-info":[{"award-number":["30972954"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81070089"],"award-info":[{"award-number":["81070089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81000095"],"award-info":[{"award-number":["81000095"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Specialized Research Fund for the Doctoral Program of Higher Education in China","award":["20100141120070"],"award-info":[{"award-number":["20100141120070"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities of China","doi-asserted-by":"crossref","award":["20103020201000193"],"award-info":[{"award-number":["20103020201000193"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities of China","doi-asserted-by":"crossref","award":["201130202020007"],"award-info":[{"award-number":["201130202020007"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The cytoplasmic signaling protein tumor necrosis factor (TNF) receptor\u2010associated factor 5 (TRAF5), which was identified as a signal transducer for members of the TNF receptor super\u2010family, has been implicated in several biological functions in T\/B lymphocytes and the innate immune response against viral infection. However, the role of TRAF5 in cardiac hypertrophy has not been reported. In the present study, we investigated the effect of TRAF5 on the development of pathological cardiac hypertrophy induced by transthoracic aorta constriction (TAC) and further explored the underlying molecular mechanisms. Cardiac hypertrophy and function were evaluated with echocardiography, hemodynamic measurements, pathological and molecular analyses. For the first time, we found that TRAF5 deficiency substantially aggravated cardiac hypertrophy, cardiac dysfunction and fibrosis in response to pressure overload after 4 weeks of TAC compared to wild\u2010type (WT) mice. Moreover, the mitogen\u2010activated protein\/extracellular signal\u2010regulated kinase kinase (MEK)\u2010extracellular signal\u2010regulated kinases 1\/2 (ERK1\/2) signaling pathway was more activated in TRAF5\u2010deficient mice than WT mice. In conclusion, our results suggest that as an intrinsic cardioprotective factor, TRAF5 plays a crucial role in the development of cardiac hypertrophy through the negative regulation of the MEK\u2010ERK1\/2 pathway. J. Cell. Biochem. 115: 349\u2013358, 2014. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.24669","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T13:30:03Z","timestamp":1378992603000},"page":"349-358","source":"Crossref","is-referenced-by-count":28,"title":["Disruption of Tumor Necrosis Factor Receptor Associated Factor 5 Exacerbates Pressure Overload Cardiac Hypertrophy and Fibrosis"],"prefix":"10.1002","volume":"115","author":[{"given":"Zhouyan","family":"Bian","sequence":"first","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 PR China"},{"name":"Cardiovascular Research Institute of Wuhan University Wuhan 430060 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 PR China"},{"name":"Cardiovascular Research Institute of Wuhan University Wuhan 430060 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nakano","family":"Hiroyasu","sequence":"additional","affiliation":[{"name":"Department of Immunology Juntendo University, School of Medicine Tokyo Japan"},{"name":"Core Research for Evolutional Science and Technology (CREST) Japan Science and Technology Corporation Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjing","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Gan","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute of Wuhan University Wuhan 430060 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 PR China"},{"name":"Cardiovascular Research Institute of Wuhan University Wuhan 430060 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zong","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 PR China"},{"name":"Cardiovascular Research Institute of Wuhan University Wuhan 430060 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangfang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 PR China"},{"name":"Cardiovascular Research Institute of Wuhan University Wuhan 430060 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Difei","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongliang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 PR China"},{"name":"Cardiovascular Research Institute of Wuhan University Wuhan 430060 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qizhu","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 PR China"},{"name":"Cardiovascular Research Institute of Wuhan University Wuhan 430060 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.21.13353"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31044"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00633.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.135665"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-012-0883-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00620.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053412"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.03.009"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.106.079426"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000077012.11088.BC"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1474"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.18.9437"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05088.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903786106"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.180117"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.07.012"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00124.2004"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.106.085399"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.656835"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1008397107"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813450601093583"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/385540a0"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.219295"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(97)00616-1"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.25.14661"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.4697"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.17.9803"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/18465"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.868554"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2009.11.012"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00054.2009"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.7.1576"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-007-0685-9"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00605.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.11.5059-5068.2001"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05084.x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104837200"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009172"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-008-0423-2"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2004.tb00262.x"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp237"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.24669","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.24669","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T07:17:50Z","timestamp":1696403870000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.24669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,13]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1002\/jcb.24669"],"URL":"https:\/\/doi.org\/10.1002\/jcb.24669","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,13]]}}}