{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T19:30:30Z","timestamp":1781983830660,"version":"3.54.5"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T00:00:00Z","timestamp":1397520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>M\u00e9ni\u00e8re's disease (MD) is a common disorder of the inner ear whose hallmarks are vertigo, tinnitus, aural fullness, and progressive hearing loss. The degree of severity of the disease is quite heterogeneous, and so is its pathogenesis. A multifactorial inheritance of intrinsic and extrinsic factors has been described, but there is not a common agreement on the molecular basis of MD. In a recent article, we have demonstrated that patients suffering from MD share a common plasma proteomic signature, characterized by the presence of several up\u2010 and down\u2010regulated proteins. In this study, we have further extended our analysis and show that the differential expression of plasma proteins can identify specific subsets of MD\u2010affected individuals, depending on their stage. Our findings confirm our plasma proteomics\u2010driven approach as a powerful tool for early diagnosis of MD and uncover a potentially starring role for some proteins in the development and fate of this frustrating disease, whose pathogenesis still remains unclear. J. Cell. Biochem. 115: 1097\u20131100, 2014. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.24747","type":"journal-article","created":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T13:07:03Z","timestamp":1387458423000},"page":"1097-1100","source":"Crossref","is-referenced-by-count":12,"title":["A Proteomics\u2010Driven Assay Defines Specific Plasma Protein Signatures in Different Stages of M\u00e9ni\u00e8re's Disease"],"prefix":"10.1002","volume":"115","author":[{"given":"G.","family":"Chiarella","sequence":"first","affiliation":[{"name":"Audiology and Phoniatrics Unit Department of Experimental and Clinical Medicine Magna Graecia University of Catanzaro Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Di Domenico","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Biophysics, and General Pathology Second University of Naples Naples Italy"},{"name":"Sbarro Institute for Cancer Research and Molecular Medicine Center for Biotechnology Temple University Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Petrolo","sequence":"additional","affiliation":[{"name":"Audiology and Phoniatrics Unit Department of Experimental and Clinical Medicine Magna Graecia University of Catanzaro Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Saccomanno","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine Laboratory of Proteomics and Mass Spectrometry Magna Graecia University of Catanzaro Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Rothenberger","sequence":"additional","affiliation":[{"name":"Sbarro Institute for Cancer Research and Molecular Medicine Center for Biotechnology Temple University Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Giordano","sequence":"additional","affiliation":[{"name":"Sbarro Institute for Cancer Research and Molecular Medicine Center for Biotechnology Temple University Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Costanzo","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine Laboratory of Proteomics and Mass Spectrometry Magna Graecia University of Catanzaro Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Cassandro","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Salerno Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Cuda","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine Laboratory of Proteomics and Mass Spectrometry Magna Graecia University of Catanzaro Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2010.05.001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22737"},{"issue":"4","key":"e_1_2_6_4_1","first-page":"238","article-title":"Bilateral transverse sinus stenosis in patients with tinnitus","volume":"32","author":"Chiarella G","year":"2012","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100003947"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000286213"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_2_6_8_1","article-title":"M\u00e9moire sur des l\u00e9sions de l'oreille interne donnant liieu \u00e0 des symptomes de congestion c\u00e9r\u00e8brale apoplectiforme","volume":"16","author":"M\u00e9ni\u00e8re P","year":"1861","journal-title":"Gazette M\u00e9dicale de Paris"},{"issue":"3","key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0194-5998(95)70102-8","article-title":"Guidelines for the diagnosis and evaluation of therapy in Meni\u00e8re's disease. American Academy of Otolaryngology\u2010Head and Neck Foundation, Inc","volume":"113","author":"Committee on Hearing and Equilibrium","year":"1995","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1179\/acb.2010.036"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200401245"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2010.05.007"},{"key":"e_1_2_6_13_1","first-page":"2310","article-title":"Uber die pathologische Veranderung bei einem Meniere Kranken","volume":"44","author":"Yamakawa Y","year":"1938","journal-title":"J Otolaryngol Soc Jpn"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.24747","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.24747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:11:44Z","timestamp":1696356704000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.24747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,15]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1002\/jcb.24747"],"URL":"https:\/\/doi.org\/10.1002\/jcb.24747","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,15]]}}}