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As HN1 is a hormone inducible gene, and has been shown that it is upregulated in various cancers, we studied the importance of HN1 function in \u03b2\u2010catenin signaling in prostate cancer cell line, PC\u20103 and mammary cancer cell line MDA\u2010MB231. Here, we demonstrated that HN1 physically associates with GSK3\u03b2\/\u03b2\u2010catenin destruction complex and abundantly localizes to cytoplasm, especially when the GSK3\u03b2 is phosphorylated on S9 residue. Further, ectopic HN1 expression results an increase in the \u03b2\u2010catenin degradation leading to loss of E\u2010cadherin interaction, concurrently contributing to actin re\u2010organization, colony formation and migration in cancer cell lines. Thus, we report that HN1 is an essential factor for \u03b2\u2010catenin turnover and signaling, augments cell growth and migration in prostate cancer cells. J. Cell. Biochem. 116: 170\u2013178, 2015. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.24956","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T12:20:19Z","timestamp":1409228419000},"page":"170-178","source":"Crossref","is-referenced-by-count":39,"title":["HN1 Negatively Influences the \u03b2\u2010Catenin\/E\u2010Cadherin Interaction, and Contributes to Migration in Prostate Cells"],"prefix":"10.1002","volume":"116","author":[{"given":"Lokman","family":"Varisli","sequence":"first","affiliation":[{"name":"Department of Bioengineering Faculty of Engineering Cancer Biology Laboratory Ege University Bornova Izmir Turkey"},{"name":"Department of Biology Art and Science Faculty Harran University Osmanbey Campus Sanliurfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilge E.","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Faculty of Engineering Cancer 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