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However, the mechanism involved in this pharmacological phenomenon is not well understood. To gain a better understanding of the underlying changes, including genes, networks and pathways altered by isoproterenol, microarray\u2010based gene expression analysis was conducted on rat parotid glands at 10, 30, and 60\u2009min after isoproterenol injection. After isoproterenol treatment, the number of differentially expressed genes was increased in a time\u2010dependent manner. Pathway analysis showed that cell hyperplasia, p38\n                      <jats:sup>MAPK<\/jats:sup>\n                      , and IGF\u20101 were the most altered function, network and pathway, respectively. The balanced regulation of up\u2010 and down\u2010expression of genes related to cell proliferation\/survival may provide a better understanding of the mechanism of isoproterenol\u2010induced parotid gland enlargement without tumor transformation. J. Cell. 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