{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:36:10Z","timestamp":1770910570574,"version":"3.50.1"},"reference-count":78,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:00:00Z","timestamp":1428624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung and Blood Institute","doi-asserted-by":"crossref","award":["R01 HL085464"],"award-info":[{"award-number":["R01 HL085464"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung and Blood Institute","doi-asserted-by":"crossref","award":["HL060014"],"award-info":[{"award-number":["HL060014"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Asthma is a pulmonary disorder, with an estimated 300 million people affected worldwide. While it is thought that endogenous reactive oxygen species (ROS) and reactive nitrogen species (RNS) such as hydrogen peroxide and nitric oxide, are important mediators of natural physiological processes, inflammatory cells recruited to the asthmatic airways have an exceptional capacity for producing a variety of highly reactive ROS and RNS believed to contribute to tissue damage and chronic airways inflammation. Antioxidant defense systems form a tightly regulated network that maintains the redox environment of the intra\u2010 as well as extracellular environment. Evidence for an oxidant\u2010antioxidant imbalance in asthmatic airways is demonstrated in a number of studies, revealing decreased total antioxidant capacity as well as lower levels of individual antioxidants. Thiols in the form of GSH and sulfhydryl groups of proteins are among the most susceptible oxidant\u2010sensitive targets, and hence, studies investigating protein thiol redox modifications in biology and disease have emerged. This perspective offers an overview of the combined efforts aimed at the elucidation of mechanisms whereby cysteine oxidations contribute to chronic inflammation and asthma, as well as insights into potential cysteine thiol\u2010based therapeutic strategies. J. Cell. Biochem. 116: 884\u2013892, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.25017","type":"journal-article","created":{"date-parts":[[2015,1,7]],"date-time":"2015-01-07T10:45:36Z","timestamp":1420627536000},"page":"884-892","source":"Crossref","is-referenced-by-count":36,"title":["Thiol Redox Chemistry: Role of Protein Cysteine Oxidation and Altered Redox Homeostasis in Allergic Inflammation and Asthma"],"prefix":"10.1002","volume":"116","author":[{"given":"Sidra","family":"Hoffman","sequence":"first","affiliation":[{"name":"Department of Pathology University of Vermont Burlington 05405 Vermont"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Nolin","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Vermont Burlington 05405 Vermont"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"McMillan","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Vermont Burlington 05405 Vermont"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiel","family":"Wouters","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine University of Maastricht Medical Center 6210 MD Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Janssen\u2010Heininger","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Vermont Burlington 05405 Vermont"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niki","family":"Reynaert","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine University of Maastricht Medical Center 6210 MD Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00208.2006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313320200"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.06.002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7961-10-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-9-6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi990240v"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1158265"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24422"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.06.006"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.06.012"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0085com"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00026108"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2001.01535.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.4.8616554"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.5056"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-0484"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201102095"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3182026370"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","unstructured":"Fitzpatrick AM Teague WG Meyers DA Peters SP Li X Li H Wenzel SE Aujla S Castro M Bacharier LB Gaston BM Bleecker ER Moore WC National Institutes of Health\/National Heart L Blood Institute Severe Asthma Research P. 2011b. Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health\/National Heart Lung and Blood Institute Severe Asthma Research Program. J Allergy Clin Immunol 127:382\u2013389 e1\u201313.","DOI":"10.1016\/j.jaci.2010.11.015"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(86)90283-7"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15262-2"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00085.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.010908.163200"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01219.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2005"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00167.2012"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2010.2.3.165"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200209-982OC"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.07.007"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.09-OA-0086"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000327501"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1552"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.03.011"},{"key":"e_1_2_6_35_1","first-page":"5626","article-title":"Structure and expression of a human class pi glutathione S\u2010transferase messenger RNA","volume":"47","author":"Kano T","year":"1987","journal-title":"Cancer Res"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1892"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2011.60"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.01969.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0423OC"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00115212"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4322"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0611-642b"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0085-4"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.10.6456"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704235"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200323575"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2012.12.005"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.04.028"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1403290"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.021394"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2011.05.003"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60988-X"},{"key":"e_1_2_6_53_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1165\/rcmb.2013-0254OC","article-title":"Histamine stimulates hydrogen peroxide production by bronchial epithelial cells via histamine H1 receptor and dual oxidase","volume":"50","author":"Rada B","year":"2014","journal-title":"Am J Respir Cell Mol Biol"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2011.01.010"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603290103"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0259RC"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.050"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.08.017"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.05.035"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.04.018"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0442OC"},{"key":"e_1_2_6_62_1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S1016-8478(23)17590-X","article-title":"Regulation by reversible S\u2010glutathionylation: Molecular targets implicated in inflammatory diseases","volume":"25","author":"Shelton MD","year":"2008","journal-title":"Mol Cells"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830261229"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2010.10.013"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00502.x"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.09.040191.001415"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00269.2005"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201107-1281OC"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200605036"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939724"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M805586200"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.124655"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni0802-715"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2011.03.004"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.9.5749"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2882fje"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00390.2002"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2989"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200801-178OC"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.25017","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.25017","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcb.25017","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.25017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T11:13:30Z","timestamp":1744197210000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.25017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,10]]},"references-count":78,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1002\/jcb.25017"],"URL":"https:\/\/doi.org\/10.1002\/jcb.25017","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,10]]}}}