{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:57:08Z","timestamp":1791928628318,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T00:00:00Z","timestamp":1439510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81100129, 81070142,81270249"],"award-info":[{"award-number":["81100129, 81070142,81270249"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Basic Research Development Program of China","award":["2012CB518604"],"award-info":[{"award-number":["2012CB518604"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Cardiac hypertrophy is the response of the heart to a variety of hypertrophic stimuli; this condition progresses to heart failure and sudden death. MicroRNAs (miRs) are a family of small, non\u2010coding RNAs that mediate posttranscriptional gene silencing. Recent studies have identified miRs as important regulators in cardiac hypertrophy. One specific miR, miR\u2010150 has been reported to be downregulated in hypertrophic murine hearts. However, the role of miR\u2010150 as a regulator of cardiac hypertrophy remains unclear. In the present study, we used gain\u2010of\u2010function and loss\u2010of\u2010function approaches to investigate the functional roles of miR\u2010150 in cardiac hypertrophy induced by aortic banding. The extent of the cardiac hypertrophy was evaluated by echocardiography and by pathological and molecular analyses of heart samples. Our results revealed that transgenic mice that overexpress miR\u2010150 in the heart were resistant to cardiac hypertrophy and fibrosis through down\u2010regulation of serum response factor (SRF). Conversely, the loss of function of miR\u2010150 by genetic knockdown or antagomiR approaches produced the opposite effects. These studies suggest that miR\u2010150 plays an important role in the regulation of cardiac hypertrophy and SRF is involved in miR\u2010150 mediated anti\u2010hypertrophic effect. Thus, miR\u2010150 may be a new therapeutic target for cardiac hypertrophy. J. Cell. Biochem. 116: 2166\u20132176, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.25057","type":"journal-article","created":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T11:16:48Z","timestamp":1420456608000},"page":"2166-2176","source":"Crossref","is-referenced-by-count":44,"title":["MicroRNA\u2010150 Protects Against Pressure Overload\u2010Induced Cardiac Hypertrophy"],"prefix":"10.1002","volume":"116","author":[{"given":"Wanli","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 China"},{"name":"Cardiovascular Research Institute, Wuhan University Wuhan 430060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 China"},{"name":"Cardiovascular Research Institute, Wuhan University Wuhan 430060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 China"},{"name":"Cardiovascular Research Institute, Wuhan University Wuhan 430060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 China"},{"name":"Cardiovascular Research Institute, Wuhan University Wuhan 430060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 China"},{"name":"Cardiovascular Research Institute, Wuhan University Wuhan 430060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 China"},{"name":"Cardiovascular Research Institute, Wuhan University Wuhan 430060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhu","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 China"},{"name":"Cardiovascular Research Institute, Wuhan University Wuhan 430060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 China"},{"name":"Cardiovascular Research Institute, Wuhan University Wuhan 430060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congxin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 China"},{"name":"Cardiovascular Research Institute, Wuhan University Wuhan 430060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 China"},{"name":"Cardiovascular Research Institute, Wuhan University Wuhan 430060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59327"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M509487200"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24669"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1582"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs013"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-062398"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.12.038"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31240"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1008397107"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811371106"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24741"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.4.470"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26505"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.030932"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2005.05.004"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.533778"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.12.5281-5289.2004"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.16"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0288OC"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000257913.42552.23"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.223172"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608791103"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007405"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.964684"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.81"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510928103"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.07.021"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1569"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.4.H1782"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-18-15"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M802663200"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24445"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.25057","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.25057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T20:04:35Z","timestamp":1696363475000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.25057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,14]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1002\/jcb.25057"],"URL":"https:\/\/doi.org\/10.1002\/jcb.25057","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,14]]}}}