{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:03:34Z","timestamp":1791306214436,"version":"4.3.1"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T00:00:00Z","timestamp":1433894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>NS5ATP9, a gene up\u2010regulated by NS5A, plays a crucial oncogenic role in several types of human tumours. However, the underlying mechanisms remain unclear. Autophagy, an evolutionarily conserved catabolic process, maintains cellular homeostasis under stress conditions, such as starvation, and plays a crucial role in tumour initiation and progression. Here, we report that NS5ATP9 mRNA and protein expression was up\u2010regulated in starved HepG2 cells and that the up\u2010regulated NS5ATP9 played a functional role in starvation\u2010induced autophagy. Overexpression or silencing of this gene showed contrasting effects on Beclin 1 and on starvation\u2010induced autophagy. Furthermore, NS5ATP9\u2010mediated autophagy is required for promotion of tumour cell growth, and this effect could be inhibited with 3\u2010methyladenine, chloroquine or by Beclin 1\u2010silencing. Thus, the mechanism for NS5ATP9\u2010promoted autophagy is Beclin 1\u2010dependent in the condition of starvation, and for hepatoblastoma cell growth is also Beclin 1\u2010dependent. J. Cell. Biochem. 116: 1574\u20131582, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.25111","type":"journal-article","created":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T22:28:47Z","timestamp":1423002527000},"page":"1574-1582","source":"Crossref","is-referenced-by-count":6,"title":["NS5ATP9 Promotes Beclin 1\u2010Dependent Starvation\u2010Induced Autophagy of Hepatoblastoma Cells"],"prefix":"10.1002","volume":"116","author":[{"given":"Min","family":"Quan","sequence":"first","affiliation":[{"name":"Department of General Medicine Beijing Ditan Hospital, Capital Medical University Beijing 100015 China"},{"name":"Institute of Infectious Diseases Beijing Ditan Hospital, Capital Medical University Beijing 100015 China"},{"name":"Beijing Key Laboratory of Emerging Infectious Diseases Beijing 100015 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunai","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Infectious Diseases Beijing Ditan Hospital, Capital Medical University Beijing 100015 China"},{"name":"Beijing Key Laboratory of Emerging Infectious Diseases Beijing 100015 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Infectious Diseases Beijing Ditan Hospital, Capital Medical University Beijing 100015 China"},{"name":"Beijing Key Laboratory of Emerging Infectious Diseases Beijing 100015 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoli","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Infectious Diseases Beijing Ditan Hospital, Capital Medical University Beijing 100015 China"},{"name":"Beijing Key Laboratory of Emerging Infectious Diseases Beijing 100015 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University Guangzhou 510120 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghu","family":"Feng","sequence":"additional","affiliation":[{"name":"Institute of Infectious Diseases Beijing Ditan Hospital, Capital Medical University Beijing 100015 China"},{"name":"Beijing Key Laboratory of Emerging Infectious Diseases Beijing 100015 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinqiu","family":"Liang","sequence":"additional","affiliation":[{"name":"Institute of Infectious Diseases Beijing Ditan Hospital, Capital Medical University Beijing 100015 China"},{"name":"Beijing Key Laboratory of Emerging Infectious Diseases Beijing 100015 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Infectious Diseases Beijing Ditan Hospital, Capital Medical University Beijing 100015 China"},{"name":"Beijing Key Laboratory of Emerging Infectious Diseases Beijing 100015 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201000089"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C100319200"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2012.44.2.033"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.20650"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1106136108"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e07-10-1092"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-6-109"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4356"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200109094"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026866"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200712051"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2011.05.024"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E05-04-0290"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712145105"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2009.09.019"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25834"},{"key":"e_1_2_6_18_1","first-page":"439","article-title":"Autophagy in metazoans: cell survival in the land of plenty. 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