{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:48:33Z","timestamp":1787237313421,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Scientific Research Council of Ataturk University","award":["2012\/352"],"award-info":[{"award-number":["2012\/352"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Cell. Biochem."],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1002\/jcb.25313","type":"journal-article","created":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T17:56:54Z","timestamp":1439834214000},"page":"638-646","source":"Crossref","is-referenced-by-count":23,"title":["The Role of RAAS Inhibition by Aliskiren on Paracetamol-Induced Hepatotoxicity Model in Rats"],"prefix":"10.1002","volume":"117","author":[{"given":"Saliha Sena","family":"Karcioglu","sequence":"first","affiliation":[{"name":"Department of Pharmacology; Faculty of Medicine; Ataturk University; Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saziye Sezin","family":"Palabiyik","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology; Faculty of Pharmacy; Ataturk University; Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasin","family":"Bayir","sequence":"additional","affiliation":[{"name":"Department of Biochemistry; Faculty of Pharmacy; Ataturk University; Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"Karakus","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology; Faculty of Veterinary Medicine; Ataturk University; Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tolga","family":"Mercantepe","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine; Recep Tayyip Erdogan University; Rize Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zekai","family":"Halici","sequence":"additional","affiliation":[{"name":"Department of Pharmacology; Faculty of Medicine; Ataturk University; Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulmecit","family":"Albayrak","sequence":"additional","affiliation":[{"name":"Department of Pharmacology; Faculty of Medicine; Ataturk University; Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,1]]},"reference":[{"key":"10.1002\/jcb.25313-BIB0001|jcb25313-cit-0001","volume-title":"Cellular and Molecular Immunology","author":"Abbas","year":"1994"},{"key":"10.1002\/jcb.25313-BIB0002|jcb25313-cit-0002","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1111\/hepr.12081","article-title":"Direct renin inhibitor, aliskiren, attenuates the progression of non-alcoholic steatohepatitis in the rat model","volume":"43","author":"Aihara","year":"2013","journal-title":"Hepatol Res"},{"key":"10.1002\/jcb.25313-BIB0003|jcb25313-cit-0003","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s00210-014-1014-0","article-title":"What is the role of renin inhibition during rat septic conditions: Preventive effect of aliskiren on sepsis-induced lung injury","volume":"387","author":"Akpinar","year":"2014","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1002\/jcb.25313-BIB0004|jcb25313-cit-0004","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/01.hjh.0000202812.72341.99","article-title":"Renin inhibition with aliskiren: Where are we now, and where are we going?","volume":"24","author":"Azizi","year":"2006","journal-title":"J Hypertens"},{"key":"10.1002\/jcb.25313-BIB0005|jcb25313-cit-0005","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1002\/jcb.25313-BIB0006|jcb25313-cit-0006","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1002\/hep.20665","article-title":"Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats","volume":"41","author":"Bataller","year":"2005","journal-title":"Hepatology"},{"key":"10.1002\/jcb.25313-BIB0007|jcb25313-cit-0007","doi-asserted-by":"crossref","first-page":"G642","DOI":"10.1152\/ajpgi.00037.2003","article-title":"Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver","volume":"285","author":"Bataller","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1002\/jcb.25313-BIB0008|jcb25313-cit-0008","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0016-5085(00)70368-4","article-title":"Angiotensin II induces contraction and proliferation of human hepatic stellate cells","volume":"118","author":"Bataller","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1002\/jcb.25313-BIB0009|jcb25313-cit-0009","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0962-8924(01)02064-5","article-title":"Signal transduction by tumor necrosis factor and its relatives","volume":"11","author":"Baud","year":"2001","journal-title":"Trends Cell Biol"},{"key":"10.1002\/jcb.25313-BIB0010|jcb25313-cit-0010","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/20014091111677","article-title":"Paracetamol (acetaminophen)-induced toxicity: Molecular and biochemical mechanisms, analogues and protective approaches","volume":"31","author":"Bessems","year":"2001","journal-title":"Crit Rev Toxicol"},{"key":"10.1002\/jcb.25313-BIB0011|jcb25313-cit-0011","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/019262339602400206","article-title":"Histopathology of acetaminophen-induced liver changes: Role of interleukin 1 alpha and tumor necrosis factor alpha","volume":"24","author":"Blazka","year":"1996","journal-title":"Toxicol Pathol"},{"key":"10.1002\/jcb.25313-BIB0012|jcb25313-cit-0012","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1006\/taap.1995.1125","article-title":"Role of proinflammatory cytokines in acetaminophen hepatotoxicity","volume":"133","author":"Blazka","year":"1995","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1002\/jcb.25313-BIB0013|jcb25313-cit-0013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI115821","article-title":"Transforming Growth-Factor-Beta in Disease - the Dark Side of Tissue-Repair","volume":"90","author":"Border","year":"1992","journal-title":"J Clin Inves"},{"key":"10.1002\/jcb.25313-BIB0014|jcb25313-cit-0014","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0076-6879(85)13062-4","article-title":"Glutathione reductase","volume":"113","author":"Carlberg","year":"1985","journal-title":"Methods Enzymol"},{"key":"10.1002\/jcb.25313-BIB0015|jcb25313-cit-0015","doi-asserted-by":"crossref","first-page":"G959","DOI":"10.1152\/ajpgi.00219.2003","article-title":"Role of p55 tumor necrosis factor receptor 1 in acetaminophen-induced antioxidant defense","volume":"285","author":"Chiu","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1002\/jcb.25313-BIB0016|jcb25313-cit-0016","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/S0026-895X(25)14551-3","article-title":"Evidence That Acetaminophen and N-Hydroxyacetaminophen Form a Common Arylating Intermediate, N-Acetyl-Para-Benzoquinoneimine","volume":"18","author":"Corcoran","year":"1980","journal-title":"Mol Pharmacol"},{"key":"10.1002\/jcb.25313-BIB0017|jcb25313-cit-0017","doi-asserted-by":"crossref","first-page":"643","DOI":"10.2146\/ajhp130149","article-title":"Probable drug-induced liver injury associated with aliskiren: Case report and review of adverse event reports from pharmacovigilance databases","volume":"71","author":"Crepin","year":"2014","journal-title":"Am J Health Syst Pharm"},{"key":"10.1002\/jcb.25313-BIB0018|jcb25313-cit-0018","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00441-011-1246-y","article-title":"TGF-beta in progression of liver disease","volume":"347","author":"Dooley","year":"2012","journal-title":"Cell Tissue Res"},{"key":"10.1002\/jcb.25313-BIB0019|jcb25313-cit-0019","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3109\/08923973.2013.775589","article-title":"The role of infliximab on paracetamol-induced hepatotoxicity in rats","volume":"35","author":"Ferah","year":"2013","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"10.1002\/jcb.25313-BIB0020|jcb25313-cit-0020","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1002\/jcb.25313-BIB0021|jcb25313-cit-0021","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jacc.2007.10.027","article-title":"Renin inhibition in hypertension","volume":"51","author":"Gradman","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1002\/jcb.25313-BIB0022|jcb25313-cit-0022","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/cc1475","article-title":"Acetaminophen toxicity: Suicidal vs. accidental","volume":"6","author":"Gyamlani","year":"2002","journal-title":"Crit Care"},{"key":"10.1002\/jcb.25313-BIB0023|jcb25313-cit-0023","first-page":"767","article-title":"Effect of renin inhibition on adipokines in diabetic rats","volume":"27","author":"Hassanin","year":"2014","journal-title":"Pak J Pharm Sci"},{"key":"10.1002\/jcb.25313-BIB0024|jcb25313-cit-0024","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/SHK.0b013e3180310f3a","article-title":"Angiotensin-converting enzyme inhibitor captopril prevents oleic acid-induced severe acute lung injury in rats","volume":"28","author":"He","year":"2007","journal-title":"Shock"},{"key":"10.1002\/jcb.25313-BIB0025|jcb25313-cit-0025","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/978-3-642-00663-0_12","article-title":"Mechanisms of acetaminophen-induced liver necrosis","author":"Hinson","year":"2010","journal-title":"Handb Exp Pharmacol"},{"key":"10.1002\/jcb.25313-BIB0026|jcb25313-cit-0026","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/toxsci\/65.2.166","article-title":"Mechanisms of hepatotoxicity","volume":"65","author":"Jaeschke","year":"2002","journal-title":"Toxicol Sci"},{"key":"10.1002\/jcb.25313-BIB0027|jcb25313-cit-0027","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3109\/03602532.2011.602688","article-title":"Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity","volume":"44","author":"Jaeschke","year":"2012","journal-title":"Drug Metab Rev"},{"key":"10.1002\/jcb.25313-BIB0028|jcb25313-cit-0028","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.cbi.2015.02.022","article-title":"Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation","volume":"231","author":"Jiang","year":"2015","journal-title":"Chem Biol Interact"},{"key":"10.1002\/jcb.25313-BIB0029|jcb25313-cit-0029","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1177\/0960327112472994","article-title":"Agomelatine: An antidepressant with new potent hepatoprotective effects on paracetamol-induced liver damage in rats","volume":"32","author":"Karakus","year":"2013","journal-title":"Hum ExpToxicol"},{"key":"10.1002\/jcb.25313-BIB0030|jcb25313-cit-0030","doi-asserted-by":"crossref","first-page":"e39739","DOI":"10.1371\/journal.pone.0039739","article-title":"Angiotensin II-Induced Mitochondrial Nox4 Is a Major Endogenous Source of Oxidative Stress in Kidney Tubular Cells","volume":"7","author":"Kim","year":"2012","journal-title":"PloS ONE"},{"key":"10.1002\/jcb.25313-BIB0031|jcb25313-cit-0031","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1161\/01.ATV.0000258415.32883.bf","article-title":"Angiotensin II induces endothelial xanthine oxidase activation: Role for endothelial dysfunction in patients with coronary disease","volume":"27","author":"Landmesser","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1002\/jcb.25313-BIB0032|jcb25313-cit-0032","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/hep.20948","article-title":"Acetaminophen-induced acute liver failure: Results of a United States multicenter, prospective study","volume":"42","author":"Larson","year":"2005","journal-title":"Hepatology"},{"key":"10.1002\/jcb.25313-BIB0033|jcb25313-cit-0033","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/0041-008X(86)90052-9","article-title":"Potential role of activated macrophages in acetaminophen hepatotoxicity. II. Mechanism of macrophage accumulation and activation","volume":"86","author":"Laskin","year":"1986","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1002\/jcb.25313-BIB0034|jcb25313-cit-0034","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/taap.1999.8635","article-title":"Inhibition of Fas receptor (CD95)-induced hepatic caspase activation and apoptosis by acetaminophen in mice","volume":"156","author":"Lawson","year":"1999","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1002\/jcb.25313-BIB0035|jcb25313-cit-0035","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1111\/j.1365-2362.2012.02725.x","article-title":"Aliskiren attenuates chronic carbon tetrachloride-induced liver injury in mice","volume":"42","author":"Lee","year":"2012","journal-title":"Eur J Clin Invest"},{"key":"10.1002\/jcb.25313-BIB0036|jcb25313-cit-0036","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev.immunol.24.021605.090737","article-title":"Transforming growth factor-beta regulation of immune responses","volume":"24","author":"Li","year":"2006","journal-title":"Ann Rev Immunol"},{"key":"10.1002\/jcb.25313-BIB0037|jcb25313-cit-0037","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1002\/jcb.25313-BIB0038|jcb25313-cit-0038","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1111\/j.1440-1746.2008.05461.x","article-title":"Liver disease and the renin-angiotensin system: Recent discoveries and clinical implications","volume":"23","author":"Lubel","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1002\/jcb.25313-BIB0039|jcb25313-cit-0039","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1089\/ars.2009.2695","article-title":"Mitochondrial glutathione, a key survival antioxidant","volume":"11","author":"Mari","year":"2009","journal-title":"Antioxid Redox Signal"},{"key":"10.1002\/jcb.25313-BIB0040|jcb25313-cit-0040","doi-asserted-by":"crossref","first-page":"e46568","DOI":"10.1371\/journal.pone.0046568","article-title":"Interaction of TNF with angiotensin II contributes to mitochondrial oxidative stress and cardiac damage in rats","volume":"7","author":"Mariappan","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1002\/jcb.25313-BIB0041|jcb25313-cit-0041","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0022-3565(25)29666-5","article-title":"Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione","volume":"187","author":"Mitchell","year":"1973","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1002\/jcb.25313-BIB0042|jcb25313-cit-0042","doi-asserted-by":"crossref","first-page":"E58","DOI":"10.1161\/01.RES.0000012569.55432.02","article-title":"Effects of angiotensin II infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide\/cGMP signaling","volume":"90","author":"Mollnau","year":"2002","journal-title":"Circ Res"},{"key":"10.1002\/jcb.25313-BIB0043|jcb25313-cit-0043","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1172\/JCI114643","article-title":"Cellular distribution of transforming growth factor-beta 1 and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis","volume":"85","author":"Nakatsukasa","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1002\/jcb.25313-BIB0044|jcb25313-cit-0044","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal Biochem"},{"key":"10.1002\/jcb.25313-BIB0045|jcb25313-cit-0045","doi-asserted-by":"crossref","first-page":"290","DOI":"10.2165\/00003495-198325030-00002","article-title":"Paracetamol overdosage. Pharmacological considerations and clinical management","volume":"25","author":"Prescott","year":"1983","journal-title":"Drugs"},{"key":"10.1002\/jcb.25313-BIB0046|jcb25313-cit-0046","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.biopha.2011.11.020","article-title":"Aliskiren attenuates myocardial apoptosis and oxidative stress in chronic murine model of cardiomyopathy","volume":"66","author":"Rashikh","year":"2012","journal-title":"Biomed Pharmacother"},{"key":"10.1002\/jcb.25313-BIB0047|jcb25313-cit-0047","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","article-title":"Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent","volume":"25","author":"Sedlak","year":"1968","journal-title":"Anal Biochem"},{"key":"10.1002\/jcb.25313-BIB0048|jcb25313-cit-0048","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nrc1208","article-title":"Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer","volume":"3","author":"Siegel","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"10.1002\/jcb.25313-BIB0049|jcb25313-cit-0049","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/clinchem\/34.3.497","article-title":"A simple method for clinical assay of superoxide dismutase","volume":"34","author":"Sun","year":"1988","journal-title":"Clin Chem"},{"key":"10.1002\/jcb.25313-BIB0050|jcb25313-cit-0050","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.5897\/AJPP12.658","article-title":"Protective effect of Panax ginseng against N-acetyl-p-aminophenol-induced hepatotoxicity in rats","volume":"6","author":"Uzkeser","year":"2012","journal-title":"Afr J Pharm Pharmacol"},{"key":"10.1002\/jcb.25313-BIB0051|jcb25313-cit-0051","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2165\/00003088-200847080-00002","article-title":"Clinical pharmacokinetics and pharmacodynamics of aliskiren","volume":"47","author":"Vaidyanathan","year":"2008","journal-title":"Clin Pharmacokinet"},{"key":"10.1002\/jcb.25313-BIB0052|jcb25313-cit-0052","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ejphar.2013.08.038","article-title":"Protective effects of aliskiren on ischemia-reperfusion-induced renal injury in rats","volume":"718","author":"Wang","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"10.1002\/jcb.25313-BIB0053|jcb25313-cit-0053","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ejphar.2014.01.022","article-title":"Protective effect of Et-1 receptor antagonist bosentan on paracetamol induced acute liver toxicity in rats","volume":"726","author":"Yayla","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"10.1002\/jcb.25313-BIB0054|jcb25313-cit-0054","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3109\/0886022X.2014.991327","article-title":"Renoprotective effect of aliskiren on renal ischemia\/reperfusion injury in rats: Electron microscopy and molecular study","volume":"37","author":"Ziypak","year":"2015","journal-title":"Ren Fail"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.25313","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/jcb.25313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T21:08:35Z","timestamp":1748552915000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.25313"}},"subtitle":["E\n                    <scp>FFECT<\/scp>\n                    <scp>OF<\/scp>\n                    A\n                    <scp>LISKIREN<\/scp>\n                    <scp>ON<\/scp>\n                    H\n                    <scp>EPATOTOXICITY<\/scp>\n                    <scp>IN<\/scp>\n                    R\n                    <scp>ATS<\/scp>"],"short-title":[],"issued":{"date-parts":[[2015,9,1]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"URL":"https:\/\/doi.org\/10.1002\/jcb.25313","archive":["Portico"],"relation":{},"ISSN":["0730-2312"],"issn-type":[{"value":"0730-2312","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9,1]]}}}