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P\u2010glycoprotein (P\u2010gp) overexpression results in reduction of intracellular drug concentration with a consequence that the cytotoxicity of anti\u2010tumor drugs is decreased, which leads to MDR in K562\/ADR cells. In this study, we found that resveratrol enhanced the anti\u2010proliferative activity of bestatin in K562\/ADR cells. Co\u2010treatment with resveratrol, IC<jats:sub>50<\/jats:sub> values of bestatin in K562\/ADR cells significantly decreased and activation of caspase\u20103 and caspase\u20108 increased, which indicated that resveratrol potentiated bestatin\u2010induced apoptosis. Resveratrol increased the intracellular concentration of bestatin through inhibiting P\u2010gp function and downregulating P\u2010gp expression at mRNA and protein levels, which increased anti\u2010proliferative activity of bestatin in K562\/ADR cells. Resveratrol decreased the phosphorylation of Akt and mTOR but did not affect the phosphorylations of JNK or ERK1\/2. These results demonstrated that resveratrol could increase the anti\u2010proliferative activity of bestatin through downregulating P\u2010gp expression via suppressing the PI3K\/Akt\/mTOR signaling pathway. J. Cell. Biochem. 117: 1233\u20131239, 2016. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.25407","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T23:46:14Z","timestamp":1444779974000},"page":"1233-1239","source":"Crossref","is-referenced-by-count":59,"title":["Resveratrol Increases Anti\u2010Proliferative Activity of Bestatin Through Downregulating P\u2010Glycoprotein Expression Via Inhibiting PI3K\/Akt\/mTOR Pathway in K562\/ADR Cells"],"prefix":"10.1002","volume":"117","author":[{"given":"Li","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, College of Pharmacy Dalian Medical University China"},{"name":"Provincial Key Laboratory for Pharmacokinetics and Transport, Liaoning Dalian Medical University China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical 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