{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:43:11Z","timestamp":1780548191336,"version":"3.54.1"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T00:00:00Z","timestamp":1460073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24392079"],"award-info":[{"award-number":["24392079"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24592885"],"award-info":[{"award-number":["24592885"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Plasma kallikrein (KLKB1), a serine protease, cleaves high\u2010molecular weight kininogen to produce bradykinin, a potent vasodilator and pro\u2010inflammatory peptide. In addition, KLKB1 activates plasminogen and other leukocyte and blood coagulation factors and processes pro\u2010enkephalin, prorenin, and C3. KLKB1 has also been shown to cleave protease\u2010activated receptors in vascular smooth muscle cells to regulate the expression of epidermal growth factor receptor. In this study, we investigated KLKB1\u2010dependent inflammation and activation of protease\u2010activated receptor\u20101 in human dental pulp cells. These cells responded to KLKB1 stimulation by increasing intracellular Ca<jats:sup>2+<\/jats:sup>, upregulating cyclooxygenase\u20102, and secreting prostaglandin E<jats:sub>2<\/jats:sub>. Remarkably, SCH79797, an antagonist of protease\u2010activated receptor\u20101, blocked these effects. Thus, these data indicate that KLKB1 induces inflammatory reactions in human dental tissues via protease\u2010activated receptor 1. J. Cell. Biochem. 117: 1522\u20131528, 2016. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.25437","type":"journal-article","created":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T14:20:38Z","timestamp":1447424438000},"page":"1522-1528","source":"Crossref","is-referenced-by-count":14,"title":["Kallikrein Promotes Inflammation in Human Dental Pulp Cells Via Protease\u2010Activated Receptor\u20101"],"prefix":"10.1002","volume":"117","author":[{"given":"Tomomi","family":"Hayama","sequence":"first","affiliation":[{"name":"Department of Endodontics Nihon University School of Dentistry at Matsudo Matsudo Chiba 271\u20108587 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Kamio","sequence":"additional","affiliation":[{"name":"Department of Endodontics Nihon University School of Dentistry at Matsudo Matsudo Chiba 271\u20108587 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsu","family":"Okabe","sequence":"additional","affiliation":[{"name":"Department of Endodontics Nihon University School of Dentistry at Matsudo Matsudo Chiba 271\u20108587 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Muromachi","sequence":"additional","affiliation":[{"name":"Department of Pulp Biology and Endodontics Graduate School of Dentistry Kanagawa Dental University Yokosuka Kanagawa 238\u20108580 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Matsushima","sequence":"additional","affiliation":[{"name":"Department of Endodontics Nihon University School of Dentistry at Matsudo Matsudo Chiba 271\u20108587 Japan"},{"name":"Research Institute of Oral Science Nihon University School of Dentistry at Matsudo Matsudo Chiba 271\u20108587 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.171769"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(00)00460-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22534"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(87)90348-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-3109(99)00112-5"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2006.01156.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070523"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12794"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/35025229"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12030"},{"issue":"1","key":"e_1_2_6_13_1","first-page":"S27","article-title":"Bradykinin and neuronal injury","volume":"9","author":"Francel PC","year":"1992","journal-title":"J Neurotrauma"},{"key":"e_1_2_6_14_1","first-page":"663","article-title":"Zusammenh\u00e4nge zwischen Herzarbeit und Nierent\u00e4tigkeit","volume":"142","author":"Frey EK","year":"1926","journal-title":"Arch Klin Chir"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0143-2885.2004.00777.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)83641-4"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.02.018"},{"key":"e_1_2_6_18_1","first-page":"442","article-title":"Plasmin\u2010induced cyclooxygenase\u20102 expression via calcineurin activation in human dental pulp cells","volume":"57","author":"Kamio N","year":"2014","journal-title":"Jpn J Conserv Dent"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707491"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"8610","DOI":"10.1016\/S0021-9258(17)39516-9","article-title":"Structural organization of the human kininogen gene and a model for its evolution","volume":"260","author":"Kitamura N","year":"1985","journal-title":"J Biol Chem"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5769(02)00144-3"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00358.2011"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706371"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.066787"},{"key":"e_1_2_6_25_1","first-page":"53","article-title":"Kallikrein\u2010related peptidases in cancers of gastrointestinal tract: An inside view of their role and clinical significance","volume":"19","author":"Linardoutsos D","year":"2014","journal-title":"J BUON"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510365652"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.11.4179"},{"key":"e_1_2_6_28_1","doi-asserted-by":"crossref","first-page":"12543","DOI":"10.1016\/S0021-9258(18)37789-5","article-title":"Selective cleavage of proenkephalin\u2010derived peptides (less than 23,300 daltons) by plasma kallikrein","volume":"263","author":"Metters KM","year":"1988","journal-title":"J Biol Chem"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(83)90244-X"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-08-0096"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(81)80229-4"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24007"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(98)80203-3"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M513138200"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2005.12.007"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M709493200"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-4666(96)99998-6"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-04-0250"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2007.08.022"},{"key":"e_1_2_6_40_1","volume-title":"The dental pulp: Biologic considerations in dental procedures","author":"Selzer S","year":"1984"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00126.2002"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.068569"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.9.5796"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-11-609016"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(78)80232-5"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.052100"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.02.018"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90261-V"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12293"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2012.1998"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.25437","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.25437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T15:27:01Z","timestamp":1694878021000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.25437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,8]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1002\/jcb.25437"],"URL":"https:\/\/doi.org\/10.1002\/jcb.25437","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,8]]}}}