{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:13:22Z","timestamp":1791263602309,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T00:00:00Z","timestamp":1457222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["14\u201024\u201000022"],"award-info":[{"award-number":["14\u201024\u201000022"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les Hepatites Virales","doi-asserted-by":"publisher","award":["1154"],"award-info":[{"award-number":["1154"]}],"id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>The immunoglobulin heavy chain (<jats:italic>IGH<\/jats:italic>) locus is submitted to intra\u2010chromosomal DNA breakages and rearrangements during normal B cell differentiation that create a risk for illegitimate inter\u2010chromosomal translocations leading to a variety of B\u2010cell malignancies. In most Burkitt's and Mantle Cell lymphomas, specific chromosomal translocations juxtapose the <jats:italic>IGH<\/jats:italic> locus with a <jats:italic>CMYC<\/jats:italic> or Cyclin D1 (<jats:italic>CCND1<\/jats:italic>) gene, respectively. 3D\u2010fluorescence in situ hybridization was performed on normal peripheral B lymphocytes induced to mature in vitro from a naive state to the stage where they undergo somatic hypermutation (SHM) and class switch recombination (CSR). The <jats:italic>CCND1<\/jats:italic> genes were found very close to the <jats:italic>IGH<\/jats:italic> locus in naive B cells and further away after maturation. In contrast, the <jats:italic>CMYC<\/jats:italic> alleles became localized closer to an <jats:italic>IGH<\/jats:italic> locus at the stage of SHM\/CSR. The colocalization observed between the two oncogenes and the <jats:italic>IGH<\/jats:italic> locus at successive stages of B\u2010cell differentiation occurred in the immediate vicinity of the nucleolus, consistent with the known localization of the RAGs and AID enzymes whose function has been demonstrated in <jats:italic>IGH<\/jats:italic> physiological rearrangements. We propose that the chromosomal events leading to Mantle Cell lymphoma and Burkitt's lymphoma are favored by the colocalization of <jats:italic>CCND1<\/jats:italic> and <jats:italic>CMYC<\/jats:italic> with <jats:italic>IGH<\/jats:italic> at the time the concerned B cells undergo VDJ recombination or SHM\/CSR, respectively. J. Cell. Biochem. 117: 1506\u20131510, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.25516","type":"journal-article","created":{"date-parts":[[2016,2,13]],"date-time":"2016-02-13T12:31:34Z","timestamp":1455366694000},"page":"1506-1510","source":"Crossref","is-referenced-by-count":17,"title":["Distinct Patterns of Colocalization of the <i>CCND1<\/i> and <i>CMYC<\/i> Genes With Their Potential Translocation Partner <i>IGH<\/i> at Successive Stages of B\u2010Cell Differentiation"],"prefix":"10.1002","volume":"117","author":[{"given":"Ilya","family":"Sklyar","sequence":"first","affiliation":[{"name":"UMR8126, CNRS Universit\u00e9 Paris\u2010Sud, Institut de Canc\u00e9rologie Gustave Roussy Villejuif France"},{"name":"LIA1066 Laboratoire Franco\u2010Russe de Recherche en Oncologie Villejuif France"},{"name":"Institute of Gene Biology Russian Academy of Sciences Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga V.","family":"Iarovaia","sequence":"additional","affiliation":[{"name":"UMR8126, CNRS Universit\u00e9 Paris\u2010Sud, Institut de Canc\u00e9rologie Gustave Roussy Villejuif France"},{"name":"LIA1066 Laboratoire Franco\u2010Russe de Recherche en Oncologie Villejuif France"},{"name":"Institute of Gene Biology Russian Academy of Sciences Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey A.","family":"Gavrilov","sequence":"additional","affiliation":[{"name":"LIA1066 Laboratoire Franco\u2010Russe de Recherche en Oncologie Villejuif France"},{"name":"Institute of Gene Biology Russian Academy of Sciences Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Pichugin","sequence":"additional","affiliation":[{"name":"UMR8126, CNRS Universit\u00e9 Paris\u2010Sud, Institut de Canc\u00e9rologie Gustave Roussy Villejuif France"},{"name":"LIA1066 Laboratoire Franco\u2010Russe de Recherche en Oncologie Villejuif France"},{"name":"Peter the Great St. Petersburg Polytechnic University St. Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Germini","sequence":"additional","affiliation":[{"name":"UMR8126, CNRS Universit\u00e9 Paris\u2010Sud, Institut de Canc\u00e9rologie Gustave Roussy Villejuif France"},{"name":"LIA1066 Laboratoire Franco\u2010Russe de Recherche en Oncologie Villejuif France"},{"name":"Peter the Great St. Petersburg Polytechnic University St. Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Tsfasman","sequence":"additional","affiliation":[{"name":"UMR8126, CNRS Universit\u00e9 Paris\u2010Sud, Institut de Canc\u00e9rologie Gustave Roussy Villejuif France"},{"name":"LIA1066 Laboratoire Franco\u2010Russe de Recherche en Oncologie Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gersende","family":"Caron","sequence":"additional","affiliation":[{"name":"INSERM U917 Universit\u00e9 de Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Fest","sequence":"additional","affiliation":[{"name":"INSERM U917 Universit\u00e9 de Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Lipinski","sequence":"additional","affiliation":[{"name":"UMR8126, CNRS Universit\u00e9 Paris\u2010Sud, Institut de Canc\u00e9rologie Gustave Roussy Villejuif France"},{"name":"LIA1066 Laboratoire Franco\u2010Russe de Recherche en Oncologie Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey V.","family":"Razin","sequence":"additional","affiliation":[{"name":"LIA1066 Laboratoire Franco\u2010Russe de Recherche en Oncologie Villejuif France"},{"name":"Institute of Gene Biology Russian Academy of Sciences Moscow Russia"},{"name":"Faculty of Biology M.V. Lomonosov Moscow State University 119992 Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yegor S.","family":"Vassetzky","sequence":"additional","affiliation":[{"name":"UMR8126, CNRS Universit\u00e9 Paris\u2010Sud, Institut de Canc\u00e9rologie Gustave Roussy Villejuif France"},{"name":"LIA1066 Laboratoire Franco\u2010Russe de Recherche en Oncologie Villejuif France"},{"name":"Faculty of Biology M.V. Lomonosov Moscow State University 119992 Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-12-30"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-510511"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)00059-5"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.71.090501.150203"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2012.11.026"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-13-249"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61272"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200301"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.39.073003.110544"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050192"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026844"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1177"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050872"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.7124\/bc.000886"},{"key":"e_1_2_5_16_1","volume-title":"FISH: A practical approach","author":"Solovei I","year":"2002"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90061-6"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401849"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200211103"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.25516","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.25516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T15:27:31Z","timestamp":1694878051000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.25516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,6]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1002\/jcb.25516"],"URL":"https:\/\/doi.org\/10.1002\/jcb.25516","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,6]]}}}