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However, its direct roles in B\u2010cell responses to chemokines are poorly understood. In this study, we examined the role of STAT5A in the innate immune response. We found that STAT5A upregulated the transcription of C\u2010C motif receptor 6 (<jats:italic>Ccr6<\/jats:italic>) to induce responses to its ligand, CCL20. STAT5A transcriptional activity proceeded through binding to the interferon\u2010\u03b3 activation site (GAS) element in the CCR6 promoter in the genome of pre\u2010B cells. High levels of STAT5A and CCR6 increased CCL20\u2010dependent colony growth of pre\u2010B cells. In human B\u2010lymphoblastic lymphoma with inflammation, STAT5A phosphorylation was correlated with CCR6 expression (<jats:italic>P\u2009<\/jats:italic>&gt;\u20090.05 compared with that in cases without inflammation). In conclusion, our data supported our hypothesis that STAT5A enhanced the response of pre\u2010B cells to CCL20 to promote their growth.\u2009\u2009 J. Cell. Biochem. 117: 2630\u20132642, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.25558","type":"journal-article","created":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T12:01:50Z","timestamp":1459166510000},"page":"2630-2642","source":"Crossref","is-referenced-by-count":10,"title":["STAT5A Modulates Chemokine Receptor CCR6 Expression and Enhances Pre\u2010B Cell Growth in a CCL20\u2010Dependent Manner"],"prefix":"10.1002","volume":"117","author":[{"given":"Tatsuaki","family":"Tsuruyama","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Kyoto University Hospital, 54 Shogoin\u2010Kawaharacho Sakyo\u2010ku Kyoto 606\u20108397 Japan"},{"name":"Center for Anatomical, Pathological Forensic Medical Research Graduate School of Medicine Kyoto University, Yoshida Konoe\u2010cho Sakyo\u2010ku Kyoto 606\u20108501 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