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Human MKN45 poorly\u2010differentiated human gastric cancer cells developed carcinomatosis peritonitis upon orthotopic transplantation in nude mice. The MKN45 cells expressed the fluorescent ubiquitination\u2010based cell cycle indicator (FUCCI) that color codes the phases of the cell cycle. The intra\u2010peritoneal tumors and ascites contained mostly quiescent G<jats:sub>1<\/jats:sub>\/G<jats:sub>o<\/jats:sub> cancer cells visualized as red by FUCCI imaging. Cisplatinum (CDDP) treatment did not reduce bloody ascites, and larger tumors formed in the peritoneal cavity after CDDP treatment in an early\u2010stage carcinomatosis peritonitis orthotopic mouse model. Paclitaxel\u2010treated mice had reduced ascites, but also had large tumor masses in the peritonium after treatment with cancer cells mostly in G<jats:sub>0<\/jats:sub>\/G<jats:sub>1<\/jats:sub>, visualized by FUCCI red. In contrast, OBP\u2010301 telomerase\u2010dependent adenovirus\u2010treated mice had no ascites and only small tumor nodules consisting of cancer cells mostly in S\/G<jats:sub>2<\/jats:sub> phases in the early\u2010stage carcinomatosis peritonitis model, visualized by FUCCI green. Furthermore, OBP\u2010301 significantly reduced the size of tumors (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and ascites even in a late\u2010stage carcinomatosis peritonitis model. These results suggest that quiescent peritoneally\u2010disseminated gastric cancer cells are resistant to conventional chemotherapy, but OBP\u2010301 significantly reduced the weight of the tumors and increased survival, suggesting clinical potential. J. Cell. Biochem. 118: 3635\u20133642, 2017. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.25593","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T13:20:43Z","timestamp":1463059243000},"page":"3635-3642","source":"Crossref","is-referenced-by-count":5,"title":["Therapeutic Cell\u2010Cycle\u2010Decoy Efficacy of a Telomerase\u2010Dependent Adenovirus in an Orthotopic Model of Chemotherapy\u2010Resistant Human Stomach Carcinomatosis Peritonitis Visualized With FUCCI Imaging"],"prefix":"10.1002","volume":"118","author":[{"given":"Shuya","family":"Yano","sequence":"first","affiliation":[{"name":"AntiCancer, Inc. San Diego California"},{"name":"Department of Surgery University of California San Diego San Diego California"},{"name":"Department of Gastroenterological Surgery Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoto","family":"Takehara","sequence":"additional","affiliation":[{"name":"AntiCancer, Inc. 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Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Kagawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyoshi","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"},{"name":"Center for Innovative Clinical Medicine Okayama University Hospital Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"AntiCancer, Inc. 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