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The study was performed using male Wistar rats of 3 (control), 12, and 24 months and 3\u2010month\u2010old rats treated with CH, melatonin, and CH plus melatonin. We found that pineal eEF\u20102 is affected by aging and CH, these changes being prevented by exogenous melatonin in the case of CH\u2010treated rats. The proteomic studies show that many other proteins are affected by aging and oxidative stress in the pineal gland. The results suggest that one of the possible mechanisms underlying pineal gland dysfunction during aging is the effect of lipid peroxidation on eEF\u20102, which is a key component of protein synthesis machinery. J. Cell. Biochem. 118: 182\u2013190, 2017. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.25624","type":"journal-article","created":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T11:55:11Z","timestamp":1465818911000},"page":"182-190","source":"Crossref","is-referenced-by-count":8,"title":["Aging and Oxidative Stress Decrease Pineal Elongation Factor 2: In Vivo Protective Effect of Melatonin in Young Rats Treated With Cumene Hydroperoxide"],"prefix":"10.1002","volume":"118","author":[{"given":"Mario F.","family":"Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Faculty of Pharmacy University of Sevilla Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Arg\u00fcelles","sequence":"additional","affiliation":[{"name":"China\u2010US (Henan) Hormel Cancer Institute Zhengzhou 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