{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:05:33Z","timestamp":1785326733281,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T00:00:00Z","timestamp":1483574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Tumor necrosis factor alpha (TNF\u2010\u03b1)\u2010induced osteoclastogenesis have profound effects in states of inflammatory osteolysis such as rheumatoid arthritis, periprosthetic implant loosening, and periodontitis. However, the exact mechanisms by which TNF\u2010\u03b1 promotes RANKL\u2010induced osteoclast formation remains poorly understood. B lymphocyte\u2010induced maturation protein\u20101 (Blimp1) is a transcriptional repressor that plays crucial roles in the differentiation and\/or function of various kinds of cells including osteoclasts. A novel mechanism was identified where TNF\u2010\u03b1\u2010mediated Blimp1 expression, which contributed to RANKL\u2010induced osteoclastogenesis. It is shown that TNF\u2010\u03b1 could promote the level of Blimp1 expression during osteoclast differentiation. Silencing of Blimp1 in osteoclast precursor cells obviously attenuated the stimulatory effect of TNF\u2010\u03b1 on osteoclastogenesis. Mechanistically, TNF\u2010\u03b1\u2010induced Blimp1 expression was markedly rescued by blocking the PI3K\/Akt signaling pathway, which suggested that PI3K\/Akt signaling was involved in the regulation of TNF\u2010\u03b1\u2010stimulated Blimp1 expression. Taken together, the results established a molecular mechanism of TNF\u2010\u03b1\u2010induced osteoclasts differentiation, and provided insights into the potential contribution of Blimp1 in the regulation of osteoclastogenesis by TNF\u2010\u03b1. J. Cell. Biochem. 118: 1308\u20131315, 2017. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.25672","type":"journal-article","created":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T22:52:43Z","timestamp":1470783163000},"page":"1308-1315","source":"Crossref","is-referenced-by-count":36,"title":["Tumor Necrosis Factor Alpha Promotes Osteoclast Formation Via PI3K\/Akt Pathway\u2010Mediated Blimp1 Expression Upregulation"],"prefix":"10.1002","volume":"118","author":[{"given":"LeCheng","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Orthopedics Changzheng Hospital The Second Military Medical University Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QunFeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Changzheng Hospital The Second Military Medical University Shanghai People's Republic of 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