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The foremost cause of the disease is still unclear, however various mechanisms have been proposed to cause the disease that include amyloid hypothesis, tau hypothesis, and cholinergic hypothesis in addition to genetic factors. Various genes have been known to be involved which are APOE, PSEN1, PSEN2, and APP among others. In the present study, we have used computational methods to examine the pathogenic effects of non\u2010synonymous single nucleotide polymorphisms (SNPs) associated with ABCA7, CR1, MS4A6A, CD2AP, PSEN1, PSEN2, and APP genes. The SNPs were obtained from dbSNP database followed by identification of deleterious SNPs and prediction of their functional impact. Prediction of disease\u2010associated mutations was performed and the impact of the mutations on the stability of the protein was carried out. To study the structural significance of the computationally prioritized mutations on the proteins, molecular dynamics simulation studies were carried out. On analysis, the SNPs with IDs rs76282929 ABCA7; CR1 rs55962594; MS4A6A rs601172; CD2AP rs61747098; PSEN1 rs63750231, rs63750265, rs63750526, rs63750577, rs63750687, rs63750815, rs63750900, rs63751037, rs63751163, rs63751399; PSEN2 rs63749851; and APP rs63749964, rs63750066, rs63750734, and rs63751039 were predicted to be deleterious and disease\u2010associated having significant structural impact on the proteins. The current study proposes a precise computational methodology for the identification of disease\u2010associated SNPs. J. Cell. Biochem. 118: 1471\u20131479, 2017. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.25806","type":"journal-article","created":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T13:26:46Z","timestamp":1479994006000},"page":"1471-1479","source":"Crossref","is-referenced-by-count":7,"title":["Computational Screening and Exploration of Disease\u2010Associated Genes in Alzheimer's Disease"],"prefix":"10.1002","volume":"118","author":[{"given":"Salma","family":"Jamal","sequence":"first","affiliation":[{"name":"Department of Bioscience and Biotechnology Banasthali University Tonk Rajasthan India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukriti","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology Banasthali University Tonk Rajasthan India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asheesh","family":"Shanker","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology Banasthali University Tonk Rajasthan India"},{"name":"Bioinformatics Programme Centre for Biological Sciences Central University of South Bihar BIT Campus Patna Bihar India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhinav","family":"Grover","sequence":"additional","affiliation":[{"name":"School of Biotechnology Jawaharlal Nehru University New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth0410-248"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S51571"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61349-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444902003451"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1934"},{"key":"e_1_2_6_7_1","volume-title":"Early\u2010onset familial Alzheimer disease","author":"Bird TD","year":"1999"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b158"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki375"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti1109"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl423"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64538-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.1"},{"key":"e_1_2_6_14_1","unstructured":"Dementia Fact sheet N\u00b0362. 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