{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T06:14:05Z","timestamp":1781244845179,"version":"3.54.1"},"reference-count":110,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T00:00:00Z","timestamp":1492732800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T00:00:00Z","timestamp":1492732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL-74185"],"award-info":[{"award-number":["HL-74185"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Cell. Biochem."],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1002\/jcb.25841","type":"journal-article","created":{"date-parts":[[2016,12,17]],"date-time":"2016-12-17T15:34:14Z","timestamp":1481988854000},"page":"2108-2117","source":"Crossref","is-referenced-by-count":32,"title":["Hypermethylation: Causes and Consequences in Skeletal Muscle Myopathy"],"prefix":"10.1002","volume":"118","author":[{"given":"Avisek","family":"Majumder","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics; School of Medicine; University of Louisville; Louisville Kentucky 40202"},{"name":"Department of Physiology; School of Medicine; University of Louisville; Louisville Kentucky 40202"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotirmaya","family":"Behera","sequence":"additional","affiliation":[{"name":"Department of Physiology; School of Medicine; University of Louisville; Louisville Kentucky 40202"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevena","family":"Jeremic","sequence":"additional","affiliation":[{"name":"Department of Physiology; School of Medicine; University of Louisville; Louisville Kentucky 40202"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh C.","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics; School of Medicine; University of Louisville; Louisville Kentucky 40202"},{"name":"Department of Physiology; School of Medicine; University of Louisville; Louisville Kentucky 40202"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,21]]},"reference":[{"issue":"5","key":"10.1002\/jcb.25841-BIB0001|jcb25841-cit-0001","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s40620-015-0235-8","article-title":"The C677T MTHFR genotypes influence the efficacy of B9 and B12 vitamins supplementation to lowering plasma total homocysteine in hemodialysis","volume":"29","author":"Achour","year":"2016","journal-title":"J Nephrol"},{"key":"10.1002\/jcb.25841-BIB0002|jcb25841-cit-0002","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/ajcn\/75.4.616","article-title":"High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased Km): Relevance to genetic disease and polymorphisms1,2,3","volume":"75","author":"Ames","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"10.1002\/jcb.25841-BIB0003|jcb25841-cit-0003","first-page":"167","article-title":"Vitamin B12 supplementation in end stage renal diseases: A systematic review","volume":"29","author":"Amini","year":"2015","journal-title":"Med J Islam Repub Iran"},{"issue":"1","key":"10.1002\/jcb.25841-BIB0004|jcb25841-cit-0004","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.phrs.2003.07.009","article-title":"Folic acid and vitamin E supplementation effects on homocysteinemia, endothelial function and plasma antioxidant capacity in young myocardial-infarction patients","volume":"49","author":"Assanelli","year":"2004","journal-title":"Pharmacol Res"},{"issue":"1","key":"10.1002\/jcb.25841-BIB0005|jcb25841-cit-0005","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1161\/01.RES.0000108264.67601.2C","article-title":"Hyperhomocysteinemia activates nuclear factor-kappaB in endothelial cells via oxidative stress","volume":"94","author":"Au-Yeung","year":"2003","journal-title":"Circ Res"},{"key":"10.1002\/jcb.25841-BIB0006|jcb25841-cit-0006","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.cmet.2012.01.001","article-title":"Acute exercise remodels promoter methylation in human skeletal muscle","volume":"15","author":"Barre's","year":"2012","journal-title":"Cell Metab"},{"key":"10.1002\/jcb.25841-BIB0007|jcb25841-cit-0007","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1046\/j.1365-2362.1999.00419.x","article-title":"Plasma homocysteine concentration related to diet, endothelial function and mononuclear cell gene expression among male hyperlipidaemic smokers","volume":"29","author":"Brude","year":"1999","journal-title":"Eur J Clin Investig"},{"issue":"1","key":"10.1002\/jcb.25841-BIB0008|jcb25841-cit-0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0100-879X2009007500021","article-title":"Genetics of homocysteine metabolism and associated disorders","volume":"43","author":"Brustolin","year":"2010","journal-title":"Braz J Med Biol Res"},{"key":"10.1002\/jcb.25841-BIB0009|jcb25841-cit-0009","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s13256-015-0662-0","article-title":"Multidisciplinary approach and anesthetic management of a surgical cancer patient with methylene tetrahydrofolate reductase deficiency: A case report and review of the literature","volume":"9","author":"Cascella","year":"2015","journal-title":"J Med Case Rep"},{"key":"10.1002\/jcb.25841-BIB0010|jcb25841-cit-0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10545-006-0106-5","article-title":"Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: An overview","volume":"29","author":"Castro","year":"2006","journal-title":"J Inherit Metab Dis"},{"issue":"11","key":"10.1002\/jcb.25841-BIB0011|jcb25841-cit-0011","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1093\/jn\/135.11.2524","article-title":"Proteomic analysis reveals changes in the liver protein pattern of rats exposed to dietary folate deficiency","volume":"135","author":"Chanson","year":"2005","journal-title":"J Nutr"},{"issue":"7","key":"10.1002\/jcb.25841-BIB0012|jcb25841-cit-0012","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physiolgenomics.00168.2013","article-title":"Differential regulation of DNA methylation versus histone acetylation in cardiomyocytes during HHcy in vitro and in vivo: An epigenetic mechanism","volume":"46","author":"Chaturvedi","year":"2014","journal-title":"Physiol Genomics"},{"issue":"1","key":"10.1002\/jcb.25841-BIB0013|jcb25841-cit-0013","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1089\/acm.2011.0113","article-title":"Effect of yoga on serum homocysteine and nitric oxide levels in adolescent women with and without dysmenorrhea","volume":"19","author":"Chien","year":"2013","journal-title":"J Altern Complement Med"},{"key":"10.1002\/jcb.25841-BIB0014|jcb25841-cit-0014","doi-asserted-by":"crossref","first-page":"503","DOI":"10.4162\/nrp.2015.9.5.503","article-title":"Poor nutrition and alcohol consumption are related to high serum homocysteine level at post-stroke","volume":"5","author":"Choi","year":"2015","journal-title":"Nutr Res Pract"},{"issue":"4","key":"10.1002\/jcb.25841-BIB0015|jcb25841-cit-0015","first-page":"480","article-title":"Phospholipid methylation in the calcium-dependent release of arachidonate for prostaglandin synthesis in renal medulla","volume":"104","author":"Craven","year":"1984","journal-title":"J Lab Clin Med"},{"issue":"6","key":"10.1002\/jcb.25841-BIB0016|jcb25841-cit-0016","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.nutres.2016.03.010","article-title":"A combination of omega -3 fatty acids, folic acid and B-group vitamins is superior at lowering homocysteine than omega -3 alone: A meta-analysis","volume":"36","author":"Dawsona","year":"2016","journal-title":"Nutr Res"},{"key":"10.1002\/jcb.25841-BIB0017|jcb25841-cit-0017","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4103\/1735-1995.189669","article-title":"Effect of folic acid and metformin on insulin resistance and inflammatory factors of obese children and adolescents","volume":"21","author":"Dehkordi","year":"2016","journal-title":"J Res Med Sci"},{"issue":"3","key":"10.1002\/jcb.25841-BIB0018|jcb25841-cit-0018","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1677\/joe.0.1690453","article-title":"Peroxisome proliferator-activated receptors in inflammation control","volume":"169","author":"Delerive","year":"2001","journal-title":"J Endocrinol"},{"key":"10.1002\/jcb.25841-BIB0019|jcb25841-cit-0019","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1182\/blood-2003-09-3078","article-title":"Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice","volume":"103","author":"Devlin","year":"2004","journal-title":"Blood"},{"key":"10.1002\/jcb.25841-BIB0020|jcb25841-cit-0020","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1074\/mcp.M900406-MCP200","article-title":"The nutrigenetics of hyperhomocysteinemia","volume":"9","author":"DiBello","year":"2010","journal-title":"Mol Cell Proteomics"},{"key":"10.1002\/jcb.25841-BIB0021|jcb25841-cit-0021","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1146\/annurev-clinpsy-032210-104518","article-title":"Gene-environment interaction in psychological traits and disorders","volume":"7","author":"Dick","year":"2013","journal-title":"Annu Rev Clin Psychol"},{"key":"10.1002\/jcb.25841-BIB0022|jcb25841-cit-0022","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1001\/archinte.165.12.1388","article-title":"Effect of lowering of homocysteine levels on inflammatory markers","volume":"165","author":"Durga","year":"2005","journal-title":"Arch Intern Med"},{"key":"10.1002\/jcb.25841-BIB0023|jcb25841-cit-0023","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/j.bbadis.2013.05.013","article-title":"Global protein and histone arginine methylation are affected in a tissue-specific manner in a rat model of diet-induced hyperhomocysteinemia","volume":"1832","author":"Esse","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1002\/jcb.25841-BIB0024|jcb25841-cit-0024","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1096\/fj.13-246579","article-title":"Protein arginine hypomethylation in a mouse model of cystathionine \u03b2-synthase deficiency","volume":"28","author":"Esse","year":"2014","journal-title":"FASEB J"},{"key":"10.1002\/jcb.25841-BIB0025|jcb25841-cit-0025","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1073\/pnas.062066299","article-title":"A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status","volume":"99","author":"Friso","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/jcb.25841-BIB0026|jcb25841-cit-0026","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1741-7007-7-38","article-title":"Expression of the peroxisome proliferator activated receptor gamma gene is repressed by DNA methylation in visceral adipose tissue of mouse models of diabetes","volume":"7","author":"Fujiki","year":"2009","journal-title":"BMC Biol"},{"key":"10.1002\/jcb.25841-BIB0027|jcb25841-cit-0027","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000085536","article-title":"Physical training decreases total plasma homocysteine and cysteine in middle-aged subjects","volume":"49","author":"Gaume","year":"2005","journal-title":"Ann Nutr Metab"},{"issue":"2","key":"10.1002\/jcb.25841-BIB0028|jcb25841-cit-0028","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/ajcn\/82.2.335","article-title":"A proinflammatory state is associated with hyperhomocysteinemia in the elderly","volume":"82","author":"Gori","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1002\/jcb.25841-BIB0029|jcb25841-cit-0029","first-page":"E725","article-title":"Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis","volume":"266","author":"Greenhaff","year":"1994","journal-title":"Am J Physiol"},{"issue":"19","key":"10.1002\/jcb.25841-BIB0030|jcb25841-cit-0030","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1161\/CIRCULATIONAHA.110.956839","article-title":"Epigenetic modifications: Basic mechanisms and role in cardiovascular disease","volume":"123","author":"Handy","year":"2011","journal-title":"Circulation"},{"key":"10.1002\/jcb.25841-BIB0031|jcb25841-cit-0031","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1475-2891-3-4","article-title":"Homocysteine and reactive oxygen species in metabolic syndrome, type 2 diabetes mellitus, and atheroscleropathy: The pleiotropic effects of folate supplementation","volume":"3","author":"Hayden","year":"2004","journal-title":"Nutr J"},{"issue":"1","key":"10.1002\/jcb.25841-BIB0032|jcb25841-cit-0032","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/00335510500429821","article-title":"Increased levels of C-reactive protein and interleukin-6 in hyperhomocysteinemic subjects","volume":"66","author":"Holven","year":"2006","journal-title":"Scand J Clin Lab Invest"},{"issue":"S-6","key":"10.1002\/jcb.25841-BIB0033|jcb25841-cit-0033","first-page":"195","article-title":"Effect of folic acid supplementation on plasma homocysteine in obese children: A randomized, double-blind, placebo-controlled trial","volume":"97","author":"Iamopas","year":"2015","journal-title":"J Med Assoc Thai"},{"issue":"4","key":"10.1002\/jcb.25841-BIB0034|jcb25841-cit-0034","doi-asserted-by":"crossref","first-page":"303","DOI":"10.5455\/msm.2016.28.303-306","article-title":"Hyperhomocysteinemia and its treatment in patients with parkinson's disease","volume":"28","author":"Ibrahimagic","year":"2016","journal-title":"Mater Sociomed"},{"key":"10.1002\/jcb.25841-BIB0035|jcb25841-cit-0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2015.04.067","article-title":"MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in hippocampus of wild-type offspring","volume":"300","author":"Jadavji","year":"2015","journal-title":"Neuroscience"},{"key":"10.1002\/jcb.25841-BIB0036|jcb25841-cit-0036","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0002-9343(02)01269-X","article-title":"Homocysteine levels and decline in physical function: MacArthur studies of successful aging","volume":"113","author":"Kado","year":"2002","journal-title":"Am J Med"},{"issue":"6","key":"10.1002\/jcb.25841-BIB0037|jcb25841-cit-0037","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1203\/00006450-197606000-00008","article-title":"Morphologic studies in a patient with homocystinuria due to 5, 10-methylenetetrahydrofolate reductase deficiency","volume":"10","author":"Kanwar","year":"1976","journal-title":"Pediatr Res"},{"key":"10.1002\/jcb.25841-BIB0038|jcb25841-cit-0038","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s11010-015-2383-5","article-title":"Hydrogen sulfide mitigates homocysteine mediated pathological remodeling by inducing miR-133a in cardiomyocytes","volume":"404","author":"Kesherwani","year":"2015","journal-title":"Mol Cell Biochem"},{"key":"10.1002\/jcb.25841-BIB0039|jcb25841-cit-0039","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/cbf.2938","article-title":"Homocysteine induces energy imbalance in rat skeletal muscle:Iscreatine a protector","volume":"31","author":"Kolling","year":"2013","journal-title":"Cell Biochem Funct"},{"key":"10.1002\/jcb.25841-BIB0040|jcb25841-cit-0040","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin modifications and their function","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell"},{"key":"10.1002\/jcb.25841-BIB0041|jcb25841-cit-0041","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ijdevneu.2010.02.006","article-title":"Effects of maternal hyperhomocysteinemia induced by methionine intake on oxidative stress and apoptosis in pup rat brain","volume":"28","author":"Koz","year":"2010","journal-title":"Int J Dev Neurosci"},{"issue":"5","key":"10.1002\/jcb.25841-BIB0042|jcb25841-cit-0042","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/(SICI)1098-1004(1999)13:5<362::AID-HUMU4>3.0.CO;2-K","article-title":"Cystathionine? synthase mutations in homocystinuria","volume":"13","author":"Kraus","year":"1999","journal-title":"Hum Mutat"},{"issue":"1-2","key":"10.1002\/jcb.25841-BIB0043|jcb25841-cit-0043","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s11010-009-0194-2","article-title":"Matrix imbalance by inducing expression of metalloproteinase and oxidative stress in cochlea of hyperhomocysteinemic mice","volume":"332","author":"Kundu","year":"2009","journal-title":"Mol Cell Biochem"},{"key":"10.1002\/jcb.25841-BIB0044|jcb25841-cit-0044","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.autrev.2007.03.008","article-title":"Hyperhomocysteinemia, inflammation and autoimmunity","volume":"6","author":"Lazzerini","year":"2007","journal-title":"Autoimmun Rev"},{"issue":"1","key":"10.1002\/jcb.25841-BIB0045|jcb25841-cit-0045","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.taap.2012.01.026","article-title":"Homocysteine enhances MMP-9 production in murine macrophages via ERK and Akt signaling pathways","volume":"260","author":"Lee","year":"2012a","journal-title":"Toxicol Appl Pharmacol"},{"issue":"5","key":"10.1002\/jcb.25841-BIB0046|jcb25841-cit-0046","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/ijc.27338","article-title":"MTHFR Polymorphisms, folate intake, and carcinogen DNA adducts in the lung","volume":"131","author":"Lee","year":"2012b","journal-title":"Int J Cancer"},{"issue":"7","key":"10.1002\/jcb.25841-BIB0047|jcb25841-cit-0047","doi-asserted-by":"crossref","first-page":"e0130421","DOI":"10.1371\/journal.pone.0130421","article-title":"Homocysteine induces collagen I expression by downregulatin histone methyltransferase G9a","volume":"10","author":"Lei","year":"2015","journal-title":"PLoS ONE"},{"issue":"8","key":"10.1002\/jcb.25841-BIB0048|jcb25841-cit-0048","doi-asserted-by":"crossref","first-page":"17682","DOI":"10.3390\/ijms160817682","article-title":"MiR-30b is involved in the homocysteine-induced apoptosis in human coronary artery endothelial cells by regulating the expression of caspase 3","volume":"16","author":"Li","year":"2015","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1002\/jcb.25841-BIB0049|jcb25841-cit-0049","doi-asserted-by":"crossref","first-page":"12560","DOI":"10.3390\/ijms160612560","article-title":"Homocysteine triggers inflammatory responses in macrophages through inhibiting CSE-H2S signaling via DNA hypermethylation of CSE promoter","volume":"16","author":"Li","year":"2015","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1002\/jcb.25841-BIB0050|jcb25841-cit-0050","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/humu.9280","article-title":"The cystathionine-synthase (CBS) mutation c.1224-2A>C in Central Europe: Vitamin B6 nonresponsiveness and a common ancestral haplotype","volume":"24","author":"Linnebank","year":"2004","journal-title":"Hum Mutat"},{"key":"10.1002\/jcb.25841-BIB0051|jcb25841-cit-0051","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nature08514","article-title":"Human DNA methylomes at base resolution show widespread epigenomic differences","volume":"462","author":"Lister","year":"2009","journal-title":"Nature"},{"key":"10.1002\/jcb.25841-BIB0052|jcb25841-cit-0052","doi-asserted-by":"crossref","first-page":"904501","DOI":"10.1155\/2014\/904501","article-title":"Suppression effects of betaine-enriched spinach on hyperhomocysteinemia induced by guanidinoacetic acid and choline deficiency in rats","volume":"2014","author":"Liu","year":"2014","journal-title":"Sci World J"},{"key":"10.1002\/jcb.25841-BIB0053|jcb25841-cit-0053","doi-asserted-by":"crossref","first-page":"29147","DOI":"10.1074\/jbc.M403618200","article-title":"DNA methylation polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E","volume":"279","author":"Lund","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1002\/jcb.25841-BIB0054|jcb25841-cit-0054","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/2044-5040-1-21","article-title":"Aberrant repair and fibrosis development in skeletal muscle","volume":"1","author":"Mann","year":"2011","journal-title":"Skelet Muscle"},{"issue":"5","key":"10.1002\/jcb.25841-BIB0055|jcb25841-cit-0055","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1586\/14789450.2.5.719","article-title":"Histone structure and nucleosome stability","volume":"2","author":"Mari\u00f1o-Ram\u00edrez","year":"2005","journal-title":"Expert Rev Proteomics"},{"issue":"4","key":"10.1002\/jcb.25841-BIB0056|jcb25841-cit-0056","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1167\/iovs.14-16190","article-title":"Retinal ganglion cell loss and mild vasculopathy in methylene tetrahydrofolate reductase (Mthfr)-Deficient mice: A model of mild hyperhomocysteinemia","volume":"56","author":"Markand","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1002\/jcb.25841-BIB0057|jcb25841-cit-0057","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/nrm1761","article-title":"The diverse functions of histone lysine methylation","volume":"6","author":"Martin","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7","key":"10.1002\/jcb.25841-BIB0058|jcb25841-cit-0058","first-page":"1","article-title":"Developmental periods of choline sensitivity provide an ontogenetic mechanism for regulating memory capacity and age-related dementia","volume":"1","author":"Meck","year":"2008","journal-title":"Logo Front Integneuro"},{"issue":"1","key":"10.1002\/jcb.25841-BIB0059|jcb25841-cit-0059","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s10194-016-0652-7","article-title":"The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients","volume":"17","author":"Menon","year":"2016","journal-title":"J Headache Pain"},{"key":"10.1002\/jcb.25841-BIB0060|jcb25841-cit-0060","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1475-2840-9-49","article-title":"Synergism in hyperhomocysteinemia and diabetes: Role of PPAR gamma and tempol","volume":"9","author":"Mishra","year":"2010","journal-title":"Cardiovasc Diabetol"},{"issue":"3","key":"10.1002\/jcb.25841-BIB0061|jcb25841-cit-0061","doi-asserted-by":"crossref","first-page":"98","DOI":"10.15171\/jnp.2016.18","article-title":"The association between atorvastatin administration and plasma total homocysteine levels in renal transplant recipients","volume":"5","author":"Monfared","year":"2016","journal-title":"J Nephropathol"},{"issue":"5","key":"10.1002\/jcb.25841-BIB0062|jcb25841-cit-0062","doi-asserted-by":"crossref","first-page":"C1009","DOI":"10.1152\/ajpcell.00353.2001","article-title":"Mechanism of constrictive vascular remodeling by homocysteine: Role of PPAR","volume":"282","author":"Mujumdar","year":"2002","journal-title":"Am J Physiol Cell Physiol"},{"issue":"6","key":"10.1002\/jcb.25841-BIB0063|jcb25841-cit-0063","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.nutres.2013.04.008","article-title":"Exercise prevents hyperhomocysteinemia in a dietary folate-restricted mouse model","volume":"33","author":"Neuman","year":"2013","journal-title":"Nutr Res"},{"key":"10.1002\/jcb.25841-BIB0064|jcb25841-cit-0064","unstructured":"2016"},{"issue":"2","key":"10.1002\/jcb.25841-BIB0065|jcb25841-cit-0065","first-page":"e25","article-title":"Homocysteine and markers of inflammation in acute coronary syndrome","volume":"15","author":"Oudi","year":"2010","journal-title":"Exp Clin Cardiol"},{"key":"10.1002\/jcb.25841-BIB0066|jcb25841-cit-0066","doi-asserted-by":"crossref","first-page":"721","DOI":"10.33549\/physiolres.932542","article-title":"Effect of the MTHFR 677C\/T polymorphism on homocysteinemia in response to creatine supplementation: A case study","volume":"62","author":"Petr","year":"2013","journal-title":"Physiol Res"},{"issue":"2","key":"10.1002\/jcb.25841-BIB0067|jcb25841-cit-0067","doi-asserted-by":"crossref","first-page":"246","DOI":"10.2337\/dc09-1516","article-title":"Effects of metformin with or without supplementation with folate on homocysteine levels and vascular endothelium of women with polycystic ovary syndrome","volume":"33","author":"Palomba","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1002\/jcb.25841-BIB0068|jcb25841-cit-0068","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000275963","article-title":"Moderate or supranormal folic acid supplementation does not exert a protective effect for homocysteinemia and methylation markers in growing rats","volume":"56","author":"Partearroyo","year":"2010","journal-title":"Ann Nutr Metab"},{"key":"10.1002\/jcb.25841-BIB0069|jcb25841-cit-0069","unstructured":"Picker JD Levy HL 2014"},{"issue":"1","key":"10.1002\/jcb.25841-BIB0070|jcb25841-cit-0070","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/07315724.2011.10719939","article-title":"Folic acid effects on s-adenosylmethionine, s-adenosylhomocysteine, and DNA methylation in patients with intermediate hyperhomocysteinemia","volume":"30","author":"Pizzolo","year":"2011","journal-title":"J Am Coll Nutr"},{"issue":"5","key":"10.1002\/jcb.25841-BIB0071|jcb25841-cit-0071","first-page":"344","article-title":"Increasing plasma homocysteine during follow-up in heart transplant recipients: Effects of folate and renal function","volume":"1","author":"Potena","year":"2000","journal-title":"Ital Heart J"},{"issue":"2","key":"10.1002\/jcb.25841-BIB0072|jcb25841-cit-0072","first-page":"78","article-title":"Dietary choline and betaine intakes and risk of cardiovascular diseases: Review of epidemiological evidence","volume":"7","author":"Rajaie","year":"2011","journal-title":"ARYA Atheroscler"},{"issue":"1","key":"10.1002\/jcb.25841-BIB0073|jcb25841-cit-0073","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3390\/nu8010034","article-title":"Effect of folic acid, betaine, vitamin B6, and vitamin B12 on homocysteine and dimethylglycine levels in middle-aged men drinking white wine","volume":"8","author":"Rajdl","year":"2016","journal-title":"Nutrients"},{"key":"10.1002\/jcb.25841-BIB0074|jcb25841-cit-0074","doi-asserted-by":"crossref","unstructured":"Reis RP Azinheira J Reis HP 2016 5 2","DOI":"10.1364\/LS.2016.LF2H.4"},{"issue":"6","key":"10.1002\/jcb.25841-BIB0075|jcb25841-cit-0075","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1093\/ajcn\/71.6.1448","article-title":"Dietary strategies for lowering homocysteine concentrations","volume":"71","author":"Riddell","year":"2000","journal-title":"Am J Clin Nutr"},{"issue":"2","key":"10.1002\/jcb.25841-BIB0076|jcb25841-cit-0076","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1089\/obe.2007.0019","article-title":"Obesity and polycystic ovary syndrome","volume":"3","author":"Sam","year":"2007","journal-title":"Obes Manag"},{"key":"10.1002\/jcb.25841-BIB0077|jcb25841-cit-0077","doi-asserted-by":"crossref","unstructured":"Schwahn B Laryea M Chen Z Melnyk S Pogribny I Garrow T Rozen R 2004 382 Pt3 831 -840","DOI":"10.1042\/BJ20030822"},{"issue":"2","key":"10.1002\/jcb.25841-BIB0078|jcb25841-cit-0078","doi-asserted-by":"crossref","first-page":"82","DOI":"10.2174\/157340310791162659","article-title":"The role of asymmetric dimethylarginine (ADMA) in endothelial dysfunction and cardiovascular disease","volume":"6","author":"Sibal","year":"2010","journal-title":"Curr Cardiol Rev"},{"issue":"4","key":"10.1002\/jcb.25841-BIB0079|jcb25841-cit-0079","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.thromres.2006.11.008","article-title":"Homocysteine, reactive oxygen species and nitric oxide in type 2 diabetes mellitus","volume":"120","author":"Signorello","year":"2007","journal-title":"Thromb Res"},{"issue":"10","key":"10.1002\/jcb.25841-BIB0080|jcb25841-cit-0080","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.3390\/nu5103920","article-title":"Nutrient intake values for folate during pregnancy and lactation vary widely around the world","volume":"5","author":"Stamm","year":"2013","journal-title":"Nutrients"},{"issue":"7","key":"10.1002\/jcb.25841-BIB0081|jcb25841-cit-0081","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1089\/ars.2010.3721","article-title":"Mechanisms of cardiovascular remodeling in hyperhomocysteinemia","volume":"15","author":"Steed","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"10.1002\/jcb.25841-BIB0082|jcb25841-cit-0082","first-page":"849","article-title":"Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene","volume":"9","author":"Stern","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"12","key":"10.1002\/jcb.25841-BIB0083|jcb25841-cit-0083","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.3945\/jn.109.113670","article-title":"One-carbon metabolism-genome interactions in folate-associated pathologies","volume":"139","author":"Stover","year":"2009","journal-title":"J Nutr"},{"issue":"1","key":"10.1002\/jcb.25841-BIB0084|jcb25841-cit-0084","first-page":"43","article-title":"A comparative study on pathogenic effects of homocysteine and cysteine on atherosclerosis","volume":"38","author":"Su","year":"2009","journal-title":"Wei Sheng Yan Jiu"},{"issue":"4","key":"10.1002\/jcb.25841-BIB0085|jcb25841-cit-0085","first-page":"78","article-title":"Effect of folic acid supplementation on homocysteine level in postmenopausal women","volume":"19","author":"Sultan","year":"2007","journal-title":"J Ayub Med Coll Abbottabad"},{"issue":"2","key":"10.1002\/jcb.25841-BIB0086|jcb25841-cit-0086","doi-asserted-by":"crossref","first-page":"256","DOI":"10.4103\/1319-2442.178255","article-title":"Effect of vitamin B12 supplementation on serum homocysteine in patients undergoing hemodialysis: A randomized controlled trial","volume":"27","author":"Tayebi","year":"2016","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"10.1002\/jcb.25841-BIB0087|jcb25841-cit-0087","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cyto.2007.07.191","article-title":"Interleukin-10 is upregulated by nanomolar rosiglitazone treatment of mature dendritic cells and human CD4+ T cells","volume":"39","author":"Thompson","year":"2007","journal-title":"Cytokine"},{"issue":"5-6","key":"10.1002\/jcb.25841-BIB0088|jcb25841-cit-0088","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1024\/0300-9831.79.56.319","article-title":"Determinants of homocysteine levels in ivorian rural population","volume":"79","author":"Tiahou","year":"2009","journal-title":"Int J Vitam Nutr Res"},{"issue":"1","key":"10.1002\/jcb.25841-BIB0089|jcb25841-cit-0089","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/jcp.21757","article-title":"Activation of GABA-A receptor ameliorates homocysteine-Induced MMP -9 activation by ERK pathway","volume":"220","author":"Tyagi","year":"2009","journal-title":"J Cell Physiol"},{"key":"10.1002\/jcb.25841-BIB0090|jcb25841-cit-0090","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1468-1331.2009.02752.x","article-title":"Elevated cerebrospinal fluid and plasma homocysteine levels in ALS","volume":"17","author":"Valentino","year":"2010","journal-title":"Eur J Neurol"},{"issue":"5","key":"10.1002\/jcb.25841-BIB0091|jcb25841-cit-0091","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1093\/ndt\/gfl044","article-title":"Why is homocysteine elevated in renal failure and what can be expected from homocysteine-lowering","volume":"21","author":"Van Guldener","year":"2006","journal-title":"Nephrol Dial Transplant"},{"issue":"7","key":"10.1002\/jcb.25841-BIB0092|jcb25841-cit-0092","doi-asserted-by":"crossref","first-page":"15074","DOI":"10.3390\/ijms140715074","article-title":"Defective homocysteine metabolism: Potential implications for skeletal muscle malfunction","volume":"14","author":"Veeranki","year":"2013","journal-title":"Int J Mol Sci"},{"key":"10.1002\/jcb.25841-BIB0093|jcb25841-cit-0093","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.3390\/ijms16011252","article-title":"Mechanisms of hyperhomocysteinemia induced skeletal muscle myopathy after ischemia in the CBS\u2212\/+ mouse model","volume":"16","author":"Veeranki","year":"2015","journal-title":"Int J Mol Sci"},{"key":"10.1002\/jcb.25841-BIB0094|jcb25841-cit-0094","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.bbadis.2015.01.008","article-title":"Hyperhomocysteinemia associated skeletal muscle weakness involves mitochondrial dysfunction and epigenetic modifications","volume":"5","author":"Veeranki","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"10.1002\/jcb.25841-BIB0095|jcb25841-cit-0095","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1161\/01.ATV.21.4.573","article-title":"Decreased smooth muscle cell\/extracellular matrix ratio of media of femoral artery in patients with atherosclerosis and hyperhomocysteinemia","volume":"21","author":"Vermeulen","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1002\/jcb.25841-BIB0096|jcb25841-cit-0096","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1042\/bj3520817","article-title":"Homocysteine stimulates nuclear factor \u03baB activity and monocyte chemoattractant protein-1 expression in vascular smooth-muscle cells: A possible role for protein kinase C","volume":"352","author":"Wang","year":"2000","journal-title":"Biochem J"},{"key":"10.1002\/jcb.25841-BIB0097|jcb25841-cit-0097","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1182\/blood.V99.3.939","article-title":"Cyclin A transcriptional suppression is the major mechanism mediating homocysteine-induced endothelial cell growth inhibition","volume":"99","author":"Wang","year":"2002","journal-title":"Blood"},{"issue":"Pt A","key":"10.1002\/jcb.25841-BIB0098|jcb25841-cit-0098","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.phrs.2016.09.002","article-title":"Homocysteine and hydrogen sulfide in epigenetic, metabolic and microbiota related renovascular hypertension","volume":"113","author":"Weber","year":"2016","journal-title":"Pharmacol Res"},{"key":"10.1002\/jcb.25841-BIB0099|jcb25841-cit-0099","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/978-1-4419-6366-6_16","article-title":"Mechanisms of skeletal muscle weakness","volume":"682","author":"Westerblad","year":"2010","journal-title":"Adv Exp Med Biol"},{"issue":"7","key":"10.1002\/jcb.25841-BIB0100|jcb25841-cit-0100","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1139\/cjpp-2014-0059","article-title":"Exercise mitigates the adverse effects of hyperhomocysteinemia on macrophages, MMP-9, skeletal muscle, and white adipocytes","volume":"92","author":"Winchester","year":"2014","journal-title":"Can J Physiol Pharmacol"},{"issue":"7","key":"10.1002\/jcb.25841-BIB0101|jcb25841-cit-0101","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1139\/cjpp-2014-0520","article-title":"Homocysteine elicits an M1 phenotype in murine macrophages through an EMMPRIN-mediated pathway","volume":"93","author":"Winchester","year":"2015","journal-title":"Can J Physiol Pharmacol"},{"issue":"9","key":"10.1002\/jcb.25841-BIB0102|jcb25841-cit-0102","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.jocn.2013.11.043","article-title":"Supplementation of folic acid and vitamin B12 reduces plasma levels of asymmetric dimethylarginine in patients with acute ischemic stroke","volume":"21","author":"Xia","year":"2014","journal-title":"J Clin Neurosci"},{"issue":"9","key":"10.1002\/jcb.25841-BIB0103|jcb25841-cit-0103","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1039\/C4AN02355B","article-title":"Crosstalk of homocysteinylation, methylation and acetylation on histone H3","volume":"140","author":"Chen","year":"2015","journal-title":"Analyst"},{"key":"10.1002\/jcb.25841-BIB0104|jcb25841-cit-0104","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-94-017-7417-8_2","article-title":"Non-coding RNAs: An introduction","volume":"886","author":"Yang","year":"2016","journal-title":"Adv Exp Med Biol"},{"key":"10.1002\/jcb.25841-BIB0105|jcb25841-cit-0105","doi-asserted-by":"crossref","first-page":"29318","DOI":"10.1074\/jbc.M002725200","article-title":"Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation","volume":"275","author":"Yi","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1002\/jcb.25841-BIB0106|jcb25841-cit-0106","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.nutr.26.061505.111156","article-title":"Choline: Critical role during fetal development and dietary requirements in adults","volume":"26","author":"Zeisel","year":"2006","journal-title":"Annu Rev Nutr"},{"issue":"23","key":"10.1002\/jcb.25841-BIB0107|jcb25841-cit-0107","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1097\/00029330-200712010-00013","article-title":"Dysfunction of endothelial NO system originated from homocysteine-induced aberrant methylation pattern in promoter region of DDAH2 gene","volume":"120","author":"Zhang","year":"2007","journal-title":"Chin Med J (Engl)"},{"key":"10.1002\/jcb.25841-BIB0108|jcb25841-cit-0108","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1476-511X-13-134","article-title":"Notable epigenetic role of hyperhomocysteinemia in atherogenesis","volume":"13","author":"Zhou","year":"2014","journal-title":"Lipids Health Dis"},{"key":"10.1002\/jcb.25841-BIB0109|jcb25841-cit-0109","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1212\/01.wnl.0000297193.53986.6f","article-title":"Elevated plasma homocysteine levels in patients with amyotrophic lateral sclerosis","volume":"70","author":"Zoccolella","year":"2008","journal-title":"Neurology"},{"key":"10.1002\/jcb.25841-BIB0110|jcb25841-cit-0110","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1007\/s00415-012-6464-z","article-title":"Elevated plasma homocysteine levels in patients with multiple sclerosis are associated with male gender","volume":"259","author":"Zoccolella","year":"2012","journal-title":"J Neurol"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.25841","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.25841","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/jcb.25841","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T18:18:18Z","timestamp":1749838698000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.25841"}},"subtitle":["H<scp>YPERMETHYLATION<\/scp>M<scp>EDIATES<\/scp>M<scp>ODULATION<\/scp><scp>OF<\/scp>M<scp>USCLE<\/scp>M<scp>YOPATH<\/scp>"],"short-title":[],"issued":{"date-parts":[[2017,4,21]]},"references-count":110,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"URL":"https:\/\/doi.org\/10.1002\/jcb.25841","archive":["Portico"],"relation":{},"ISSN":["0730-2312"],"issn-type":[{"value":"0730-2312","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4,21]]}}}