{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:24:11Z","timestamp":1760909051359},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T00:00:00Z","timestamp":1487203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Plan for Science Technology and Innovation","award":["11-BIO-2020-03"],"award-info":[{"award-number":["11-BIO-2020-03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label \/><jats:p>The purpose of the current study was to find out the possible changes polymorphic site at the promoter region of IL\u201018 gene in Saudi CAD patients. We have also measured serum IL\u201018 level to find out, the likely association between its level and polymorphic site. The present study included total 197 subjects (98 confirmed CAD patients both men and women and 99 healthy control individuals). Serum concentration of IL\u201018 was measured by enzyme linked immuno\u2010sorbent assay. For SNPs analysis, sanger method of DNA sequencing was followed. We observed variable numbers of SNPs at \u2212137\u2009C\/G, \u2212607\u2009A\/C, and \u2212656\u2009T\/G promoter sites in our studied samples. However, the observed changes in the number of SNP hotspots were found to be non\u2010significant compared with control. IL\u201018 level was found to be significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) elevated in CAD patients compared with control individuals. The highest rise of around 36% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) in IL\u201018 level was recorded in unstable angina (UA) patients. Moreover, the group belonging to UA and non\u2010ST segment elevation myocardial infarction (NSTEMI) showed only 6% rise. On the basis of our result, inflammation seems to have a role in the pathogenesis of CAD but not leading to the significant changes at the genetic level. J. Cell. Biochem. 118: 1849\u20131854, 2017. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.25870","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T10:57:16Z","timestamp":1483700236000},"page":"1849-1854","source":"Crossref","is-referenced-by-count":15,"title":["Assessment of IL\u201018 Serum Level and Its Promoter Polymorphisms in the Saudi Coronary Artery Disease (CAD) Patients"],"prefix":"10.1002","volume":"118","author":[{"given":"Nasimudeen R.","family":"Jabir","sequence":"first","affiliation":[{"name":"King Fahd Medical Research Center King Abdulaziz University Jeddah Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelapram K.","family":"Firoz","sequence":"additional","affiliation":[{"name":"King Fahd Medical Research Center King Abdulaziz University Jeddah Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad 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