{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T23:18:14Z","timestamp":1784243894464,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T00:00:00Z","timestamp":1496793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Ovarian cancer is one of the most common malignant tumor of female genital organs which ranks the third morbidity. We aimed to provide a better understanding of the mechanism of invasion and metastasis of ovarian cancer. The ovarian cancer samples were downloaded from GEO. Then clustering was performed to classify the stage of miRNAs based on the difference of prognosis and metastasis. Furthermore, the miRNAs model was build and the survival analysis processes was performed to observe the influence on prognosis, invasion and metastasis. At last, miRNAs co\u2010expression network was built to explore the core miRNAs and the risk classification model was built to perform the risk assessment based on these core miRNAs. A total of 17 significantly differential expressed miRNAs were obtained. Functional enrichment of 1,488 target genes, pathways like cell cycle, focal adhesion, and pathways in cancer, which are closely related to the proliferation and metastasis of cancer cells were highly enriched, this indicate that these miRNAs are related to the proliferation and metastasis of cancer cells. The co\u2010expressed network shows that the high expression of hsa\u2010miR\u2010320 indicated negative prognosis and high risk of metastasis. In conclusion, the expression level of hsa\u2010miR\u2010320 is highly related to the migration and invasion of cancer. The high expression of hsa\u2010miR\u2010320 directly indicated negative prognosis and high risk of metastasis. These findings reveal that hsa\u2010miR\u2010320 may serve as an important therapeutic target in ovarian cancer therapy. J. Cell. Biochem. 118: 3654\u20133661, 2017. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26009","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T16:35:53Z","timestamp":1490373353000},"page":"3654-3661","source":"Crossref","is-referenced-by-count":33,"title":["Overexpression of Hsa\u2010miR\u2010320 Is Associated With Invasion and Metastasis of Ovarian Cancer"],"prefix":"10.1002","volume":"118","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"Reproductive Center Jingzhou Central Hospital The Second Clinical Medical College Yangtze University Jingzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gynecology The Central Hospital of Wuhan Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 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