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Then Stress group was subdivided into four subgroups administered water, SSR149415 (1\u2009mg\/kg\/day), SSR149415 (10\u2009mg\/kg\/day), SSR149415 (30\u2009mg\/kg\/day), respectively. The behavioral alterations revealed by social interaction test and open field test were measured. The physical indices, including body weight and gonad weight (testis and epididymis) as well as testis\/body weight and cauda epididymis\/body weight were detected. Serum hormones, including testosterone, luteinizing hormone (LH), and follicle\u2010stimulating hormone (FSH) were determined. Sperm count and abnormality as well as testicular histology structure were assessed. The germ cells apoptosis were also evaluated. Chronic social defeat stress\u2010induced behavioral abnormality, as well as gonad atrophy (testis and epididymis) was significantly alleviated in stressed male mice exposed to SSR149415. Regressed serum testosterone levels and elevated serum FSH and LH levels exhibited by stressed male mice were observably reversed following SSR149415 administration. Chronic social defeat stress\u2010induced damage in testicular histology structure and semen quality were also improved after SSR149415 administration. In addition, SSR149415 significantly reversed chronic social defeat stress\u2010induced germ cells apoptosis. Overall, we provide clear evidence indicating the amelioration of chronic social defeat stress\u2010induced behavioral abnormality and testicular dysfunction via SSR149415, promoting the development of drug\u2010directed therapy against this disease. J. Cell. Biochem. 118: 3891\u20133898, 2017. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26040","type":"journal-article","created":{"date-parts":[[2017,4,8]],"date-time":"2017-04-08T13:43:16Z","timestamp":1491658996000},"page":"3891-3898","source":"Crossref","is-referenced-by-count":6,"title":["The Non\u2010Peptide Vasopressin V1b Receptor Antagonist, SSR149415, Ameliorates Spermatogenesis Function in a Mouse Model of Chronic Social Defeat Stress"],"prefix":"10.1002","volume":"118","author":[{"given":"Bin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Urology The First Affiliated Hospital of SooChow University SuZhou 215006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center The First Affiliated Hospital of SooChow University SuZhou 215006 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