{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:12:57Z","timestamp":1791817977006,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005969","name":"Universit\u00e0 di Bologna","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005969","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>FOXM1 transcription factor is a central component of tumor initiation, growth, and progression due to its multiple effects on cell cycle, DNA repair, angiogenesis and invasion, chromatin, protein anabolism, and cell adhesion. Moreover, FOXM1 interacts with \u03b2\u2010catenin promoting its nuclear import and transcriptional activation. Here, we show that FOXM1 is involved in the advantage of chronic myeloid leukemia hematopoiesis over the normal counterpart. FOXM1 hyper\u2010activation associated with BCR\u2010ABL1 results from phosphorylation by the fusion protein kinase\u2010dependent activation of Polo\u2010like kinase 1. FOXM1 phosphorylation lets its binding with \u03b2\u2010catenin and \u03b2\u2010catenin transcriptional activation, a key event for persistence of the leukemic stem cell compartment under tyrosine kinase inhibitor therapy. Polo\u2010like kinase 1 inhibitor BI6727, already advanced for clinical use, breaks \u03b2\u2010catenin interaction with FOXM1, hence hampering FOXM1 phosphorylation, \u03b2\u2010catenin binding, nuclear import, and downstream signaling. In conclusion, our results support Polo\u2010like kinase 1\/FOXM1 axis as a complementary target to eradicate leukemic early progenitor\/stem cell compartment in chronic myeloid leukemia. J. Cell. Biochem. 118: 3968\u20133975, 2017. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26052","type":"journal-article","created":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T06:56:40Z","timestamp":1491980200000},"page":"3968-3975","source":"Crossref","is-referenced-by-count":12,"title":["FOXM1 Transcription Factor: A New Component of Chronic Myeloid Leukemia Stem Cell Proliferation Advantage"],"prefix":"10.1002","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2972-5609","authenticated-orcid":false,"given":"Manuela","family":"Mancini","sequence":"first","affiliation":[{"name":"Department of Experimental Diagnostic and Specialty Medicine\u2014DIMES Institute of Hematology L. and A. Ser\u00e0gnoli\u2010University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto","family":"Castagnetti","sequence":"additional","affiliation":[{"name":"Department of Experimental Diagnostic and Specialty Medicine\u2014DIMES Institute of Hematology L. and A. Ser\u00e0gnoli\u2010University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Soverini","sequence":"additional","affiliation":[{"name":"Department of Experimental Diagnostic and Specialty Medicine\u2014DIMES Institute of Hematology L. and A. Ser\u00e0gnoli\u2010University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Leo","sequence":"additional","affiliation":[{"name":"Department of Experimental Diagnostic and Specialty Medicine\u2014DIMES Institute of Hematology L. and A. Ser\u00e0gnoli\u2010University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"De Benedittis","sequence":"additional","affiliation":[{"name":"Department of Experimental Diagnostic and Specialty Medicine\u2014DIMES Institute of Hematology L. and A. Ser\u00e0gnoli\u2010University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Gugliotta","sequence":"additional","affiliation":[{"name":"Department of Experimental Diagnostic and Specialty Medicine\u2014DIMES Institute of Hematology L. and A. Ser\u00e0gnoli\u2010University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianantonio","family":"Rosti","sequence":"additional","affiliation":[{"name":"Department of Experimental Diagnostic and Specialty Medicine\u2014DIMES Institute of Hematology L. and A. Ser\u00e0gnoli\u2010University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana","family":"Bavaro","sequence":"additional","affiliation":[{"name":"Department of Experimental Diagnostic and Specialty Medicine\u2014DIMES Institute of Hematology L. and A. Ser\u00e0gnoli\u2010University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"De Santis","sequence":"additional","affiliation":[{"name":"Department of Experimental Diagnostic and Specialty Medicine\u2014DIMES Institute of Hematology L. and A. Ser\u00e0gnoli\u2010University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Monaldi","sequence":"additional","affiliation":[{"name":"Department of Experimental Diagnostic and Specialty Medicine\u2014DIMES Institute of Hematology L. and A. 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