{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:12:58Z","timestamp":1791000778360,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T00:00:00Z","timestamp":1495497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007162","name":"Guangdong Science and Technology Department","doi-asserted-by":"publisher","award":["2012B031800291"],"award-info":[{"award-number":["2012B031800291"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Sepsis is one of the most challenging health problems worldwide. Our previous study showed that chronic schistosoma japonica (SJ) infection might increase serum anti\u2010inflammatory factors to play a protective role, thus improving the survival rate of septic mice. Further research revealed that SJ infection promoted J774A.1 macrophage differentiation into M2 macrophages; suppressed LPS\u2010induced activation of M1 macrophages; up\u2010regulated CD163, IL\u201010, and TGF\u2010\u03b21 expression; inhibited TNF\u2010\u03b1 and iNOS expression; and blocked the effect of LPS\u2010promoted TNF\u2010\u03b1 and iNOS expression. Furthermore, adoptive transfer of ex vivo programed M2 macrophages significantly increased the survival rate of septic mice. In vitro studies suggested that soluble egg antigen (SEA) from SJ played the same role as worm infection but had no impact on M1 macrophages. SEA reduced LPS\u2010induced TNF\u2010\u03b1 and iNOS expression, decreased the inhibitory effect of LPS on IL\u201010 and TGF\u2010\u03b21 expression, increased STAT6 phosphorylation, and up\u2010regulated PI3K and Akt expression but inhibited SOCS1 expression. When PI3K inhibitors were added, SEA\u2010induced expression of CD163, IL\u201010, and arg1 might be reduced. Therefore, worm infection has a protective effect in septic mice in which SEA may play a key role via the STAT6 and PI3K pathways. This finding may provide a favorable solution for the treatment of sepsis, especially early cases. J. Cell. Biochem. 118: 4230\u20134239, 2017. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26073","type":"journal-article","created":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T14:06:43Z","timestamp":1492438003000},"page":"4230-4239","source":"Crossref","is-referenced-by-count":40,"title":["Soluble Egg Antigen Activates M2 Macrophages via the STAT6 and PI3K Pathways, and Schistosoma Japonicum Alternatively Activates Macrophage Polarization to Improve the Survival Rate of Septic Mice"],"prefix":"10.1002","volume":"118","author":[{"given":"Hao","family":"Tang","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010bing","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine The First Affiliated Hospital Sun Yat\u2010sen 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