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In this study, we investigated the effects of homocysteine (Hcy) on the expression of histone deacetylase 1 (HDAC1) and tested our hypothesis that Hcy\u2010induced atherosclerosis is mediated by increased HDAC1 expression, which is regulated by miR\u201034a. The expression of HDAC1 increased and acetylation of histone H3 at lysine 9 (H3K9ac) decreased in the aorta of ApoE<jats:sup>\u2212\/\u2212<\/jats:sup> mice fed with high methionine diet, whereas miR\u201034a expression was inhibited. Over\u2010expression of HDAC1 inhibited H3K9ac level and promoted the accumulation of total cholesterol, free cholesterol, and triglycerides in the foam cells. Furthermore, up\u2010regulation of miR\u201034a reduced HDAC1 expression and inhibited the accumulation of total cholesterol (TC), free cholesterol (FC), and triglycerides (TG) in the foam cells. These data suggest that HDAC1\u2010related H3K9ac plays a key role in Hcy\u2010mediated lipid metabolism disorders, and that miR\u201034a may be a novel therapeutic target in Hcy\u2010related atherosclerosis. J. Cell. Biochem. 118: 4617\u20134627, 2017. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26126","type":"journal-article","created":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T12:12:10Z","timestamp":1494331930000},"page":"4617-4627","source":"Crossref","is-referenced-by-count":48,"title":["miR\u201034a Targets HDAC1\u2010Regulated H3K9 Acetylation on Lipid Accumulation Induced by Homocysteine in Foam Cells"],"prefix":"10.1002","volume":"118","author":[{"given":"Qingguo","family":"Zhao","sequence":"first","affiliation":[{"name":"Key Laboratory of Cardio\u2010Cerebro\u2010Vascular Diseases Ningxia Medical University Yinchuan Ningxia China"},{"name":"Basic Medical School Ningxia Medical University Yinchuan Ningxia 750004 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuqiang","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardio\u2010Cerebro\u2010Vascular Diseases Ningxia Medical University Yinchuan 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