{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:37:15Z","timestamp":1763642235077,"version":"3.37.3"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:00:00Z","timestamp":1498089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The 2014 Science and Technology Development Plan of Shandong Province","award":["2014GSF119022"],"award-info":[{"award-number":["2014GSF119022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>The study aims to explore the roles of common polymorphisms of Tumor Necrosis Factor\u2010\u03b1 (TNF\u2010\u03b1) (\u2010238 A\/G and \u2010308 A\/G) and IL\u201010 (\u2010819 T\/C and \u20101082 G\/A) genes in the risk of non\u2010traumatic osteonecrosis of the femoral head (NONFH). One hundred and forty\u2010seven NONFH patients and 135 healthy individuals were selected as the case and control groups. qRT\u2010PCR and Western blotting techniques detected mRNA as well as protein expressions of TNF\u2010\u03b1 and IL\u201010 of each genotype in both the case and control groups. The GA genotype and the A allele of TNF\u2010\u03b1 \u2010238 A\/G were higher in the case group than in the control group. Compared with the control group, AA, GA, and AG\u2009+\u2009AA genotypes as well as the A allele of IL\u201010\u20101082 G\/A were all lower in the case group. In the case groups increased levels of TNF\u2010\u03b1 as well as decreased levels of IL\u201010 expression when compared with the control group. TNF\u2010\u03b1 expression of TNF\u2010\u03b1\u2010238 GA genotype was significantly higher than that in patients with GG genotype, while the IL\u201010 expression of GA and AA genotypes of IL\u201010\u20101082 was significantly lower than in that of patients with the GG genotype. TNF\u2010\u03b1 protein expression in the GA genotype was significantly higher than in the GG genotype. In relation to TNF\u2010\u03b1 \u2010238, TNF\u2010\u03b1 protein expression of GA and AA genotypes had significantly reduced more so than the GG genotype in IL\u201010\u20101082. TNF\u2010\u03b1\u2010238 A\/G and IL\u201010\u20101082 G\/A may be involved as risk factors of NONFH. J. Cell. Biochem. 118: 4872\u20134880, 2017. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26167","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T16:50:56Z","timestamp":1495731056000},"page":"4872-4880","source":"Crossref","is-referenced-by-count":11,"title":["Associations of TNF\u2010\u03b1 \u2010238 A\/G and IL\u201010 \u20101082 G\/A Genetic Polymorphisms With the Risk of NONFH in the Chinese Population"],"prefix":"10.1002","volume":"118","author":[{"given":"Biao\u2010Fang","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Femoral Head Linyi People's Hospital Linyi 276000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Femoral Head Linyi People's Hospital Linyi 276000 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