{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:10:15Z","timestamp":1777468215209,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T00:00:00Z","timestamp":1497830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by a progressive loss of dopaminergic neurons in the midbrain. Several pathogenetic factors have been involved in the onset and progression of PD, including inflammation, oxidative stress, unfolded protein accumulation, and apoptosis. Ample evidence indicates that miRNAs could regulate post\u2010transcriptional gene expression and neuronal disease. In this study, we evaluated the effects and mechanism of miR\u2010124\u20103p on 6\u2010hydroxydopamine (6\u2010OHDA)\u2010induced neurotoxicity in PC12 cells and SH\u2010SY5Y cells. qRT\u2010PCR results showed that the level of miR\u2010124\u20103p was downregulated in 6\u2010OHDA\u2010treated PC12 and SH\u2010SY5Y cells, and overexpression of miR\u2010124\u20103p significantly promoted the cell viability of 6\u2010OHDA\u2010treated PC12 and SH\u2010SY5Y cells, whereas miR\u2010124\u20103p inhibitor reversed these effects. In addition, PC12 or SH\u2010SY5Y cells were treated with miR\u2010124\u20103p mimics or inhibitors following 6\u2010OHDA administration, which mediated cell apoptosis and downregulation or upregulation of Caspase\u20103 activity, respectively. A luciferase reporter assay revealed that annexinA5 (ANXA5) is a direct target gene of miR\u2010124\u20103p, and miR\u2010124\u20103p overexpression markedly downregulated the level of ANXA5. Strikingly, further analysis showed that miR\u2010124\u20103p enhanced the viability of 6\u2010OHDA\u2010treated PC12 or SH\u2010SY5Y cells by targeting ANXA5, which was associated with the stimulation of the ERK pathway. This study revealed that miR\u2010124\u20103p may play a neuroprotective role in PD; this observation may provide new ideas and therapeutic targets for PD. J. Cell. Biochem. 119: 269\u2013277, 2018. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26170","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T17:22:54Z","timestamp":1495732974000},"page":"269-277","source":"Crossref","is-referenced-by-count":68,"title":["The Neuroprotective Role of MiR\u2010124\u20103p in a 6\u2010Hydroxydopamine\u2010Induced Cell Model of Parkinson's Disease via the Regulation of ANAX5"],"prefix":"10.1002","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8861-559X","authenticated-orcid":false,"given":"Rui\u2010Fang","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Neurology Cangzhou Central Hospital Cangzhou City Hebei Province 061001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Hospital of Shijiazhuang Shijiazhuang Hebei Province 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