{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T07:18:27Z","timestamp":1778915907189,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T00:00:00Z","timestamp":1501459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20141077"],"award-info":[{"award-number":["BK20141077"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370200"],"award-info":[{"award-number":["81370200"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital heart disease. To identify endogenous peptides possibly involved in the progression of TOF, we performed comparative peptidomic profiling of maternal serum between normal fetuses and fetuses suffering from TOF. A total of 278 differentially expressed peptides, including 94 over\u2010expressed peptides and 184 under\u2010expressed peptides, originating from 227 protein precursors were identified by liquid chromatography\/mass spectrometry (LC\/MS) in maternal serum of fetuses with TOF compared to normal controls. Further, ingenuity pathway analysis (IPA) was used to identify putative roles for these peptides in cardiovascular development. Two peptides were derived from functional domains of proteins involved in heart development and associated with TOF; these may represent candidate bioactive peptides involved in TOF. These peptides may be related to the pathologic changes in the heart associated with TOF, and may be useful as novel biomarkers for prenatal diagnosis of TOF. J. Cell. Biochem. 119: 468\u2013477, 2018. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26204","type":"journal-article","created":{"date-parts":[[2017,6,9]],"date-time":"2017-06-09T11:24:48Z","timestamp":1497007488000},"page":"468-477","source":"Crossref","is-referenced-by-count":7,"title":["Peptidomic Analysis of Maternal Serum to Identify Biomarker Candidates for Prenatal Diagnosis of Tetralogy of Fallot"],"prefix":"10.1002","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6232-6856","authenticated-orcid":false,"given":"Bin","family":"Zhuang","sequence":"first","affiliation":[{"name":"Department of Pediatrics Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University Nanjing 210004 China"},{"name":"Fourth Clinical Medicine College Nanjing Medical University Nanjing 210029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University Nanjing 210004 China"},{"name":"Fourth Clinical Medicine College Nanjing Medical University Nanjing 210029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University Nanjing 210004 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengmeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University Nanjing 210004 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingai","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University Nanjing 210004 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University Nanjing 210004 China"},{"name":"Fourth Clinical Medicine College Nanjing Medical University Nanjing 210029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University Nanjing 210004 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Prenatal Diagnosis Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University Nanjing 210004 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Prenatal Diagnosis Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University Nanjing 210004 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhangbin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University Nanjing 210004 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuping","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University Nanjing 210004 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2004.10.007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.287"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60657-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37491"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-4-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.12030"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21231"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(86)80505-1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2016.05.025"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4023"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12551-009-0009-4"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11532"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh056"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep05637"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01827"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2006.01.008"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443088"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4622"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652410791065255"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445560"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.119.3.969"},{"key":"e_1_2_7_23_1","article-title":"Nonerythropoietic erythropoietin\u2010Derived peptide suppresses adipogenesis, inflammation, obesity and insulin resistance","volume":"5","author":"Liu Y","year":"2015","journal-title":"Sci Rep"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2012.10.038"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.206623"},{"key":"e_1_2_7_26_1","first-page":"238","article-title":"Analysis of low\u2010abundance, low\u2010molecular\u2010weight serum proteins using mass spectrometry","volume":"15","author":"Merrell K","year":"2005","journal-title":"J Biomol Techn"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00247-1"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201503113"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.042127"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026390"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1118"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E02-10-0685"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1586\/14789450.2013.841547"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200500878"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086652"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.103.4.1465"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-1708"},{"key":"e_1_2_7_38_1","first-page":"101","article-title":"Birth prevalence of congenital heart disease worldwide: A systematic review and meta\u2010analysis","volume":"2012","author":"Van dLD","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.57"},{"key":"e_1_2_7_40_1","first-page":"756","article-title":"Differential exoprotease activities confer tumor\u2010specific serum peptidome patterns","volume":"49","author":"Villanueva J","year":"2006","journal-title":"J Clin Invest"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1616229"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000456282"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-273409"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acuro.2013.09.015"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260972"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.05.010"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr070501k"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.26204","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.26204","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcb.26204","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.26204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T18:19:11Z","timestamp":1744568351000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.26204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,31]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/jcb.26204"],"URL":"https:\/\/doi.org\/10.1002\/jcb.26204","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,31]]}}}