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In this study, we explored the underlying mechanism involving microRNA\u2010145\u20103p (miR\u2010145\u20103p) in the development and progression of non\u2010small cell lung cancer (NSCLC) by targeting PDK1 via the mTOR signaling pathway. NSCLC tissues and adjacent normal tissues were obtained from 83 NSCLC patients. miR\u2010145\u20103p, PDK1, and mTOR levels were determined by quantitative real\u2010time polymerase chain reaction (qRT\u2010PCR) and immunohistochemistry. Human NSCLC cell lines A549 and H1299 were transfected with miR\u2010145\u20103p and siPDK1 to confirm the effect of miR\u2010145\u20103p and PDK1 on NSCLC cells in vitro. Cell growth was evaluated by a CCK8 assay. Cell motility and chemotaxis analysis were determined by the scratch test and chemotaxis assay, respectively. The protein levels of PDK1 and mTOR were measured using the western blotting. Results showed lower level of miR\u2010145\u20103p and higher levels of PDK1 and mTOR in NSCLC tissues compared to the adjacent normal tissues. In vitro results showed that cell growth, cell motility, and chemotaxis were all inhibited in cells transfected with miR\u2010145\u20103p and those transfected with siPDK. Additionally, dual luciferase reporter gene assay helped confirmed that PDK1 is a target of miR\u2010145. Finally, levels of PDK1, mTOR, and phosphorylated\u2010mTOR were lower in cells transfected with miR\u2010145\u20103p as well as those with siPDK1. These findings indicate that miR\u2010145\u20103p may inhibit cell growth, motility, and chemotaxis in NSCLC by targeting PDK1 through suppressing the mTOR pathway.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26252","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T09:50:37Z","timestamp":1498729837000},"page":"885-895","source":"Crossref","is-referenced-by-count":25,"title":["<i>Retracted:<\/i> microRNA\u2010145\u20103p inhibits non\u2010small cell lung cancer cell migration and invasion by targeting PDK1 via the mTOR signaling pathway"],"prefix":"10.1002","volume":"119","author":[{"given":"Gui\u2010Min","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Oncology Linyi Cancer Hospital Linyi P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u2010Juan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Imaging Linyi People's Hospital Linyi P. R. 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