{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:26:10Z","timestamp":1780417570988,"version":"3.54.1"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T00:00:00Z","timestamp":1504828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","award":["1393\u20101\u201091\u201013223"],"award-info":[{"award-number":["1393\u20101\u201091\u201013223"]}],"id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>Postmenopausal osteoporosis (OP) is a major concern for public health. Low\u2010level laser therapy (LLLT) has a positive effect on the health of bone marrow mesenchymal stem cells (BMMSCs). The purpose of this study is to evaluate the influence of LLLT and oxytocin (OT) incubation\u2014individually and in combination\u2014on osteoporotic BMMSCs in ovariectomized rats. Twelve female rats were randomized into two groups to undergo either a sham surgery (sham group) or ovariectomy\u2010induced osteoporosis (OVX group). MSCs harvested from the BM of healthy and OVX rats underwent culture expansion. There were five groups. In Groups one (sham\u2010BMMSC) and two (OVX\u2010BMMSC) the cells were held in osteogenic condition medium without any intervention. In the group three (OT), OT incubation with optimum dose was performed for 48\u2009h (two times, 10<jats:sup>\u221212<\/jats:sup> molar). In Group four, laser\u2010treated\u2010OVX\u2010BMMSCs were treated with optimum protocol of LLLT (one time, 1.2\u2009J\/cm<jats:sup>2<\/jats:sup>). In Group five (laser\u2009+\u2009OT group), the OT incubation plus the laser irradiation was performed. The biostimulatory effect of LLLT is demonstrated by a significant increase in the viability of OVX\u2010BMMSCs, cell cycle, and extracellular levels of Transforming growth factor beta (TGF\u2010\u03b2), insulin\u2010like growth factor\u2010I (IGF\u2010I), and Alkaline phosphatase (ALP) compared to control OVX\u2010BMMSCs and\/or the sham group. OT incubation and laser\u2009+\u2009OT incubation have a positive effect on OVX\u2010BMMSCs. However, LLLT is more effective statistically. We conclude that LLLT significantly improved cell viability, enhanced the osteogenic potential of the OVX\u2010BMMSCs, and increased the extracellular levels of the TGF\u2010\u03b2, IGF\u2010I, and ALP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26265","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T11:26:45Z","timestamp":1499340405000},"page":"983-997","source":"Crossref","is-referenced-by-count":31,"title":["Effect of low\u2010level laser therapy and oxytocin on osteoporotic bone marrow\u2010derived mesenchymal stem cells"],"prefix":"10.1002","volume":"119","author":[{"given":"Somaye","family":"Fallahnezhad","sequence":"first","affiliation":[{"name":"Department of Biology and Anatomical Sciences School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Piryaei","sequence":"additional","affiliation":[{"name":"Department of Biology and Anatomical 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