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This study was designed to explore the potential role of miR\u2010150 in regulating the process of neuropathic pain in a rat model established by chronic sciatic nerve injury (CCI). Overexpression of miR\u2010150 greatly alleviated neuropathic pain development and reduced inflammatory cytokine expression, including COX\u20102, interleukin IL\u20106, and tumor necrosis factor (TNF)\u2010\u03b1 in CCI rats. By bioinformatic analysis, 3\u2032\u2010untranslated region (UTR) of Toll\u2010like receptor (TLR5) was predicted to be a target of miR\u2010150. TLR5 commonly serves as an important regulator of inflammation. Overexpression of miR\u2010150 significantly suppressed the expression of TLR5 in vitro and in vivo. Furthermore, upregulation of TLR5 decreased the miR\u2010150 expression and downregulation of TLR5 increased miR\u2010150, respectively. Overexpression of TLR5 significantly reversed the miR\u2010150\u2010induced suppressive effects on neuropathic pain. In conclusion, our current study indicates that miR\u2010150 may inhibit neuropathic pain development of CCI rats through inhibiting TLR5\u2010mediated neuroinflammation. Our findings suggest that miR\u2010150 may provide a novel therapeutic target for neuropathic pain treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26269","type":"journal-article","created":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T13:42:36Z","timestamp":1499434956000},"page":"1017-1026","source":"Crossref","is-referenced-by-count":52,"title":["MiR\u2010150 alleviates neuropathic pain via inhibiting toll\u2010like receptor 5"],"prefix":"10.1002","volume":"119","author":[{"given":"Li\u2010Juan","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Sport Medicine and Rehabilitation Center School of Kinesiology Shanghai University of Sport Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shi","sequence":"additional","affiliation":[{"name":"Geriatric Department\uff0cThe Central Hospital of Wuhan Tongji Medical College Huazhong University of Science and Technology Wuhan 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