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Male SD rats were injected with CCl<jats:sub>4<\/jats:sub> (1\u2009mL\/kg\/i.p.\/daily) dissolved 1:1 in olive oil for 1 month. Some animals received MEL (20\u2009mg\/kg\/i.p.\/daily) diluted in 1\u2009mL PBS in combination with CCl<jats:sub>4<\/jats:sub> (co\u2010treatment), and some rats were treated with MEL, beginning with injection of the last dose of CCl<jats:sub>4<\/jats:sub> for one month (post\u2010treatment). The groups were control, CCl<jats:sub>4<\/jats:sub>, CCl<jats:sub>4<\/jats:sub>\u2010co vehicle, CCl<jats:sub>4<\/jats:sub>\u2010post vehicle, post\u2010CCl<jats:sub>4<\/jats:sub>, MEL co\u2010treatment, and MEL post\u2010treatment. MEL post\u2010treatment group showed significantly lower lipid deposition, serum malondialdehyde (MDA), serum alanine aminotransferase (ALT), and liver hydroxyproline. This group also had low expressions of Bax and transforming growth factor\u2010\u03b21 (TGF\u2010\u03b21). MEL post\u2010treatment group revealed higher sera levels of albumin, superoxide dismutase (SOD) and glutathione peroxidase (GPx). Expression levels of metalloproteinase\u201013 (MMP\u201013) and Bcl2 was also higher in this group (<jats:italic>P<\/jats:italic>\u2009\u2264\u20090.05 vs co\u2010treatment). Results of the present study indicated that MEL post\u2010treatment is more powerful in reduction of CCl<jats:sub>4<\/jats:sub>\u2010induced liver fibrosis through reduction of oxidative stress and maintenance of matrix balance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26331","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T05:58:45Z","timestamp":1502085525000},"page":"1716-1725","source":"Crossref","is-referenced-by-count":16,"title":["RETRACTED: Post\u2010treatment of melatonin with CCl<sub>4<\/sub> better reduces fibrogenic and oxidative changes in liver than melatonin co\u2010treatment"],"prefix":"10.1002","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2004-3465","authenticated-orcid":false,"given":"Keywan","family":"Mortezaee","sequence":"first","affiliation":[{"name":"Department of Anatomy, School of Medicine Kurdistan University of Medical Sciences Sanandaj Iran"},{"name":"Department of Anatomy School of Medicine Tehran 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